Document 0273
 DOCN  M9440273
 TI    p53 protein over-expression and p53 gene abnormalities in HIV-1-related
       non-Hodgkin's lymphomas.
 DT    9404
 AU    De Re V; Carbone A; De Vita S; Gloghini A; Maestro R; Gasparotto D;
       Vukosavljevic T; Boiocchi M; Division of Experimental Oncology 1, Centro
       di Riferimento; Oncologico, Aviano, Italy.
 SO    Int J Cancer. 1994 Mar 1;56(5):662-7. Unique Identifier : AIDSLINE
       MED/94148568
 AB    Alteration of the p53 tumor-suppressor gene was studied in non-Hodgkin's
       lymphomas (NHLs) from HIV-1-infected patients. p53 protein was
       over-expressed in 10 out of the 45 (22%) cases analyzed, mainly
       clustering in the small-non-cleaved-cell (SNC) (5/19) and Ki-1+
       anaplastic large-cell (ALC) (3/8) sub-types, according to previous
       findings on HIV-1-unrelated NHLs. p53-positive small-non-cleaved-cell
       lymphomas presented a diffuse or clustered pattern of p53-positive
       neoplastic cells consequent upon p53-gene mutations. In contrast, in
       Ki-1+ ALC lymphomas p53 immunohistochemical reactivity was limited to
       scattered tumor cells, and no p53-gene alterations could be detected.
       These results suggest that p53-gene alterations play a role in the
       lymphomagenetic process of a fraction of HIV-1-related SNC NHLs, however
       with a frequency no different from that observed in HIV-1-unrelated NHLs
       of the same sub-type. In HIV-1-related Ki-1+ ALC lymphomas, mechanisms
       different from gene alterations might be implicated in over-expression
       of p53 protein.
 DE    Base Sequence  Cell Nucleus/METABOLISM  Gene Expression  *Genes, p53
       Herpesvirus 4, Human/GENETICS  Human  HIV Infections/*COMPLICATIONS
       *HIV-1  Lymphoma, Non-Hodgkin's/COMPLICATIONS/*GENETICS  Molecular
       Sequence Data  Polymerase Chain Reaction  Protein p53/*METABOLISM  RNA,
       Viral/ANALYSIS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).