Document 0276
 DOCN  M9440276
 TI    The effect of ethnic differences on the pattern of HTLV-I-associated
       T-cell leukemia/lymphoma (HATL) in the United States.
 DT    9404
 AU    Levine PH; Manns A; Jaffe ES; Colclough G; Cavallaro A; Reddy G;
       Blattner WA; National Cancer Institute, Bethesda, MD 20892.
 SO    Int J Cancer. 1994 Jan 15;56(2):177-81. Unique Identifier : AIDSLINE
       MED/94148509
 AB    Human T-cell lymphotropic virus Type I (HTLV-I) is the primary etiologic
       factor for adult T-cell leukemia/lymphoma (ATL). Although HTLV-I is
       endemic in Japan and the Caribbean islands, the reported clinical and
       epidemiologic features of ATL in these 2 parts of the world are quite
       different. ATL has been diagnosed at a younger age and is reported more
       frequently as the lymphomatous type rather than the acute type with
       leukemia in the Caribbean basin as compared with the presentation in
       Japan. In order to characterize ATL in the United States, a registry has
       been established at the National Cancer Institute for the purpose of
       recording all cases originally diagnosed in the United States. This
       registry was utilized to examine the effect of ethnic differences on age
       of onset and clinical features of ATL, using the same data base.
       Clinical and laboratory information was obtained from 177 patients
       suspected of having ATL, who were treated at the National Institutes of
       Health, or had biological samples sent for evaluation, or were reported
       in the literature. Histopathologic review and virologic studies were
       performed by standardized methods. Of 177 patients registered, 127 were
       considered as having ATL, according to an algorithm combining clinical,
       pathologic and laboratory features. Presenting features in the confirmed
       cases consisted primarily of lymphadenopathy (76.6%), hypercalcemia
       (72.5%), leukemia (82%), skin involvement (48.2%) and hepatomegaly
       (53.6%). Patients of Japanese ancestry were generally older (median age
       63, range 51 to 73 years) than patients of African-American descent
       (median age 39, range 7 to 75 years) and presented more often with
       leukemia (90 vs. 69%).(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adolescence  Adult  Aged  Blacks  Child  Comparative Study  Eskimos
       *Ethnic Groups  Female  Hispanic Americans  Human
       Japan/ETHNOLOGY/EPIDEMIOLOGY  Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/*ETHNOLOGY/  EPIDEMIOLOGY  Male  Middle Age  United
       States/EPIDEMIOLOGY  Whites  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).