Document 0280
 DOCN  M9440280
 TI    The correlation between HIV seropositivity, cervical dysplasia, and HPV
       subtypes 6/11, 16/18, 31/33/35.
 DT    9404
 AU    Tweddel G; Heller P; Cunnane M; Multhaupt H; Roth K; Department of
       Obstetrics and Gynecology, Pennsylvania Hospital,; Philadelphia 19107.
 SO    Gynecol Oncol. 1994 Feb;52(2):161-4. Unique Identifier : AIDSLINE
       MED/94148273
 AB    Twenty-one human immunodeficiency virus (HIV) seropositive patients were
       studied to determine the prevalence of cervical dysplasia, the
       distribution of human papilloma virus (HPV) subtypes, and the utility of
       cytologic diagnosis in this population. The patients ranged in age from
       18 to 41 years. HIV infection was diagnosed in all patients by ELISA
       method and confirmed by Western blot. Patients were interviewed to
       document risk factors for HIV infection and cervical dysplasia. All were
       examined colposcopically and identifiable lesions were biopsied. In
       patients with normal colposcopic findings four quadrant biopsies were
       performed. Cervical and endocervical smears were obtained on all
       patients at the time of colposcopy and blood was collected for T-cell
       studies. Eighteen patients (86%) had abnormal cytologic findings. The
       Pap smear was able to identify 10 of 13 biopsy-proven epithelial
       abnormalities. In 14 patients there was sufficient tissue for HPV typing
       by in situ hybridization; the HPV subtypes identified were 6/11 (10
       patients), 16/18 (9 patients), and 31/33/35 (9 patients). Dysplasia was
       present in 11/14 (79%) of the specimens submitted for subtyping. The
       absolute CD4 cell counts were 342 per mm3 for the dysplasia group and
       281 per mm3 for the patients without dysplasia. Patients with dysplasia
       did not differ significantly from patients without dysplasia in regard
       to risk factors for cervical dysplasia, including history of STD,
       tobacco use, multiple sexual partners, age at first coitus, and parity.
       In addition, history of medication use and risk factors associated with
       HIV infection were similar in both groups.(ABSTRACT TRUNCATED AT 250
       WORDS)
 DE    Adolescence  Adult  Biopsy  Cervical Intraepithelial
       Neoplasia/COMPLICATIONS/MICROBIOLOGY/  PATHOLOGY  Cervix
       Dysplasia/*COMPLICATIONS/*MICROBIOLOGY/PATHOLOGY  Cervix
       Uteri/*MICROBIOLOGY/PATHOLOGY  Colposcopy  Female  Human  HIV
       Seropositivity/*COMPLICATIONS  Papillomavirus, Human/*ISOLATION & PURIF
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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