Document 0286
 DOCN  M9440286
 TI    Neurological dysfunction in asymptomatic HIV-1 infected men: evidence
       from evoked potentials. HNRC Group.
 DT    9404
 AU    Iragui VJ; Kalmijn J; Thal LJ; Grant I; Department of Neurosciences,
       University of California, San Diego; School of Medicine, La Jolla.
 SO    Electroencephalogr Clin Neurophysiol. 1994 Jan;92(1):1-10. Unique
       Identifier : AIDSLINE MED/94147952
 AB    Neurological function in 159 subjects infected by the human
       immunodeficiency virus (HIV) who had no neurological symptoms or signs
       (129 asymptomatic, 30 with ARC/AIDS) was compared to that of 62 controls
       by means of pattern-reversal evoked potentials (PREPs), brain-stem
       auditory evoked potentials (BAEPs), median nerve somatosensory evoked
       potentials (MSEPs), tibial nerve somatosensory evoked potentials (TSEPs)
       and nerve conduction studies (NCSs). Central nervous system
       somatosensory conduction from lumbar cord to cortex was prolonged in
       both asymptomatic seropositive and ARC/AIDS groups, while peripheral
       somatosensory conduction, NCSs and PREP delays occurred only in the
       ARC/AIDS group. BAEPs did not show significant differences among groups.
       TSEPs were abnormal in 8% of asymptomatic carriers and 43% of patients
       with ARC/AIDS, MSEPs in 7% and 20%, PREPs in 4% and 0%, and BAEPs in 1%
       and 0% respectively. One or more evoked potentials were abnormal in 18
       of 129 (14%) asymptomatic carriers and 13 of 30 (43%) subjects with
       ARC/AIDS as compared with 1 of 62 (2%) seronegative controls. We
       conclude that asymptomatic HIV carriers have subclinical neurological
       impairment of central somatosensory function and that the neurological
       impairment increases with disease progression to involve peripheral
       nerves and visual system.
 DE    Adolescence  Adult  Analysis of Variance  Electroencephalography  Evoked
       Potentials/*PHYSIOLOGY  Human  HIV Infections/*PHYSIOPATHOLOGY  *HIV-1
       Male  Middle Age  Nervous System Diseases/MICROBIOLOGY/*PHYSIOPATHOLOGY
       Neural Conduction/PHYSIOLOGY  Reaction Time/PHYSIOLOGY  Support, U.S.
       Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).