Document 0287
 DOCN  M9440287
 TI    [Intravesical instillation of BCG for the bladder cancer: relationship
       between effect and immune cells in peripheral blood and bladder wall]
 DT    9404
 AU    Chen LZ; First Affiliated Hospital of Sun Yat-sen University of Medical;
       Sciences, Guangzhou.
 SO    Chung Hua Wai Ko Tsa Chih. 1993 Jun;31(6):336-8. Unique Identifier :
       AIDSLINE MED/94147827
 AB    Immunohistochemical technique was used to investigate the immune cells
       both in the peripheral blood and the bladder wall of the bladder cancer
       patients before and after intravesical instillation of BCG. CD4+ and the
       ratio of CD4+/CD8+ in the responders were significantly higher than that
       in the nonresponders in peripheral blood. The immune cells of all the
       patients received BCG instillation were increased in the bladder wall.
       The CD4+/CD8+ ratio was 2.007 and 0.656 in responders and nonresponders
       respectively. The antitumor activity of BCG was shown by the increasing
       of CD4+ cells. The infiltrating degree of the immune cells would be
       decreased with time. It would be valuable to give maintenance treatment.
 DE    Administration, Intravesical  Adult  Aged  Bladder
       Neoplasms/IMMUNOLOGY/*THERAPY  BCG Vaccine/*THERAPEUTIC USE  CD4-CD8
       Ratio  English Abstract  Female  Human  Male  Middle Age  Neoplasm
       Recurrence, Local/THERAPY  T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL
       ARTICLE

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