Document 0289
 DOCN  M9440289
 TI    Analysis of natural killer (NK) cell subsets defined by the expression
       of two novel surface antigens (EB6 and GL183) in AIDS and AIDS-related
       conditions.
 DT    9404
 AU    Cauda R; Goletti D; Lucia MB; Tumbarello M; Rumi C; Orengo AM; Moretta
       A; Istituto di Clinica Malattie Infettive, Universita Cattolica S.;
       Cuore, Roma, Italy.
 SO    Clin Immunol Immunopathol. 1994 Mar;70(3):198-205. Unique Identifier :
       AIDSLINE MED/94147715
 AB    In this study we analyzed the expression of EB6 and GL183, which are
       part of P58 molecular family that represents the putative NK receptor
       for MHC class I molecules, in peripheral blood lymphocytes of 60
       patients with HIV infection (20 asymptomatic HIV-seropositive
       individuals, 20 patients with constitutional symptoms, and 20 AIDS
       patients) and correlated it with the level of CD4+, CD56+ cells, and the
       NK cell activity in order to determine a possible relation with disease
       progression. The absolute number (but not the percentage) of CD56+,
       EB6+, and GL183+ cells was significantly reduced only in AIDS patients
       but not in the other AIDS-related clinical conditions. On the contrary,
       NK cell activity was reduced in all HIV-infected patients. In a 6-month
       follow-up, patients with constant clinical conditions and stable CD4+
       cells level showed no significant difference, either in the percentage
       or absolute number of EB6+ and GL183+ cells. Interestingly, dual-color
       fluorescence indicates that GL183 and EB6 molecules (that in normal
       individuals are virtually absent on CD3- NK cells) are expressed in
       HIV-infected individuals not only in CD56+ cells but also in CD3+ cells.
       This may reflect a depletion of other T cell subsets or alternatively
       (less likely) a specific immune response. Our data indicate that the
       expression of EB6 and GL183 in T and NK cells from HIV-infected patients
       might be relevant in the course of the disease and for the
       disease-associated functional defect of NK cell activity.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Adult  Antigens,
       Surface/*ANALYSIS  AIDS-Related Complex/*IMMUNOLOGY  Cytotoxicity,
       Immunologic  Female  Fluorescent Antibody Technique  Human  Killer
       Cells, Natural/CLASSIFICATION/*IMMUNOLOGY  Male  Phenotype  Support,
       Non-U.S. Gov't  T-Lymphocyte Subsets/*IMMUNOLOGY  Tumor Cells,
       Cultured/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).