Document 0297
 DOCN  M9440297
 TI    Influence of physiological concentration of progesterone on CD(4+)- and
       CD(8+)-activated lymphocytes with interleukin 2 and autologous plasma:
       difference between healthy donors and patients bearing malignant tumors.
 DT    9404
 AU    Kimoto Y; Tong FZ; Taguchi T; Department of Oncologic Surgery, Osaka
       University, Japan.
 SO    Cancer Lett. 1993 Dec 20;75(3):157-65. Unique Identifier : AIDSLINE
       MED/94147372
 AB    The influence of progesterone at the physiological concentration on
       normal donor and malignant patient peripheral blood lymphocytes
       incubated with interleukin 2 (IL-2) was investigated. Analysis of the
       phenotypes of IL-2-activated lymphocytes revealed that there was a
       difference in the positive rates of CD4+ and CD8+ cells between normal
       donors and patients with malignancies. Activated lymphocytes of normal
       adults older than 35 years of age consisted of 60-100% of CD4+ cells and
       0-30% of CD8+ cells. Donors younger than 35 years of age showed a
       positive rate of CD4+ cells, ranging from 0-100%, while CD8+ cells were
       between 0-60%. However, in patients with malignancies both CD4+ and
       CD(8+)-activated lymphocytes diffused from 0-100%. Activated lymphocytes
       of most patients were CD8+ cell dominant, which reversed the CD4+/CD8+
       ratio. Almost all patients at clinical stage IV showed a deviation of
       the positive rates of CD4+ and CD8+ cells from the normal range. It is
       an open question whether the prognosis of the patients with normal
       positive rates of CD(4+)- and CD(8+)-activated lymphocytes is favorable
       or not.
 DE    Adult  Aged  Antigens, CD8  Cell Division/*DRUG EFFECTS  Comparative
       Study  CD4-CD8 Ratio/*DRUG EFFECTS  Female  Human  In Vitro
       Interleukin-2/PHARMACOLOGY  Lymphocyte Transformation  Male  Middle Age
       Neoplasm Staging  Neoplasms/*IMMUNOLOGY
       Progesterone/*PHARMACOLOGY/PHYSIOLOGY  T-Lymphocytes/*DRUG EFFECTS  T4
       Lymphocytes/DRUG EFFECTS  JOURNAL ARTICLE

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