Document 0302
 DOCN  M9440302
 TI    Interleukin 1 beta inhibits synaptic strength and long-term potentiation
       in the rat CA1 hippocampus.
 DT    9404
 AU    Bellinger FP; Madamba S; Siggins GR; Department of Neuropharmacology,
       Scripps Research Institute, La; Jolla, CA 92037.
 SO    Brain Res. 1993 Nov 19;628(1-2):227-34. Unique Identifier : AIDSLINE
       MED/94147137
 AB    Cytokines such as interleukin-1 beta (IL-1 beta) are released in the
       nervous system following inflammation or infection. Recently, IL-1 beta
       was shown to enhance synaptic inhibitory mechanisms. We therefore
       investigated the effect of IL-1 beta superfusion on long-term
       potentiation (LTP), the cellular model of memory and learning, evoked in
       the CA1 region by tetanic stimulation of the stratum radiatum in the rat
       hippocampal slice. IL-1 beta (150 pM-1.5 nM) superfused 10 min before
       tetanic stimulation significantly reduced LTP of the slope of the
       population excitatory postsynaptic potential (pEPSP) and the population
       spike (PS) amplitude in CA1 in a concentration-dependent manner. IL-1
       beta (1.5 nM) applied for 10 min 1 h before tetanus significantly
       inhibited LTP of the PS amplitude and pEPSP slope and reduced pEPSP and
       PS values before tetanus as well, although the PS returned to control
       values before tetanus. Heat-inactivated IL-1 beta had no effect on
       pre-tetanus pEPSP or PS values or the induction of LTP. These data
       demonstrate that IL-1 beta modulates synaptic potentials and reduces
       LTP. These findings have important implications for the role of IL-1
       beta in neuronal disorders following infection, perhaps best exemplified
       by HIV-1-associated dementia.
 DE    Animal  Heat  Hippocampus/*DRUG EFFECTS  In Vitro
       Interleukin-1/*PHARMACOLOGY  Long-Term Potentiation/*DRUG EFFECTS  Rats
       Rats, Sprague-Dawley  Serum Albumin, Bovine/PHARMACOLOGY  Support, U.S.
       Gov't, P.H.S.  Synaptic Transmission/*DRUG EFFECTS  Tetany/PREVENTION &
       CONTROL  JOURNAL ARTICLE

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