Document 0310
 DOCN  M9440310
 TI    Incidence of HIV-1 infection in a rural region of Uganda.
 DT    9404
 AU    Wawer MJ; Sewankambo NK; Berkley S; Serwadda D; Musgrave SD; Gray RH;
       Musagara M; Stallings RY; Konde-Lule JK; Center for Population and
       Family Health, Columbia University; School of Public Health, New York,
       NY 10032.
 SO    BMJ. 1994 Jan 15;308(6922):171-3. Unique Identifier : AIDSLINE
       MED/94146627
 AB    OBJECTIVE--To determine the incidence of infection with HIV-1 and the
       risk factors associated with seroconversion in three geographical strata
       of a rural Ugandan district. DESIGN--Serological, sociodemographic, and
       behavioural surveys of everyone aged 13 or more in 21 randomly selected
       communities at baseline and one year later. SETTING--Rural population of
       Rakai district, southwestern Uganda, residing in main road trading
       centres, secondary trading villages, and agricultural villages.
       SUBJECTS--In 1989, 1292 adults provided a blood sample and interview
       data; one year later, 778 survivors (77%) who had been seronegative at
       baseline provided follow up data. MAIN OUTCOME MEASURES--Incidence of
       HIV infection in relation to individual characteristics and risk
       factors, including place of residence. RESULTS--Incidence of HIV
       infection in all adults was 2.1/100 person years of observation (SE 0.5
       (95% confidence interval 1.1 to 3.1)); in people aged 15-39 the
       incidence was 3.2/100 person years. Incidence was highest in men and
       women aged 20-24 (9.2/100 person years (3.9) and 6.8/100 person years
       (2.9) respectively). Risk factors significantly associated with
       seroconversion were age 24 and under and two or more sexual partners.
       Between the surveys the proportion of all respondents reporting high
       risk behaviour (two or more partners) significantly increased from 8.9%
       to 12.3%. CONCLUSIONS--Despite preventive programmes and substantial
       knowledge about AIDS the incidence of HIV infection remains high in this
       rural population. Prevention aimed at vulnerable rural communities is
       urgently needed to contain the HIV epidemic.
 DE    Adolescence  Adult  Aged  Cohort Studies  Female  Human  HIV
       Infections/*EPIDEMIOLOGY  *HIV-1  Incidence  Male  Middle Age  Risk
       Factors  *Rural Health  Sex Factors  Socioeconomic Factors  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't,
       P.H.S.  Uganda/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).