Document 0339
 DOCN  M9440339
 TI    Neonatal disease induced by SIV infection of the rhesus monkey (Macaca
       mulatta).
 DT    9404
 AU    Bohm RP Jr; Martin LN; Davison-Fairburn B; Baskin GB; Murphey-Corb M;
       Department of Veterinary Sciences, Tulane Regional Primate; Research
       Center (TRPRC), Covington, Louisiana 70433.
 SO    AIDS Res Hum Retroviruses. 1993 Nov;9(11):1131-7. Unique Identifier :
       AIDSLINE MED/94145748
 AB    Seven 72-hr-old Indian origin rhesus monkeys (Macaca mulatta) were
       inoculated with 10 animal ID50 of SIV/DeltaB670. Nine age-matched
       animals were used as uninoculated controls. All seven inoculated animals
       became infected as verified by viral isolation and SIV p26 antigenemia.
       Five of seven infected animals died within a mean of 31 days (range,
       26-41 days), with high levels of antigenemia beginning 1-2 weeks
       postinoculation (PI) that persisted until death. Absolute lymphocyte
       numbers were within normal limits in all animals in both groups
       throughout the study. Inoculated animals that died within a mean of 31
       days (short-term survivors) had significantly lower numbers of CD4+CD29+
       (helper/inducer) lymphocytes than did long-term surviving inoculated
       animals through 3 weeks PI. Numbers of CD4+ lymphocytes were no
       different when controls were compared to all inoculated animals through
       4-5 weeks PI. The two inoculated animals surviving 216 and 423 days PI
       (long-term survivors) did demonstrate declining CD4+ cells, but only
       late in disease. CD8+ lymphocytes were significantly lower in short-term
       survivors when compared to long-term survivors through 5 weeks PI.
       Antibody production against SIV viral proteins was detected only in the
       long-term survivors and was similar to results from past studies in
       juveniles. Clinical signs in the inoculated group were consistent with
       those seen in past studies on older animals. Persistent bacterial
       infections, primarily of the GI and respiratory tracts, were seen in the
       infected group. Aside from the lack of some opportunistic infections
       such as cytomegalovirus (CMV) and Pneumocystis carinii, necropsy
       findings were not different when compared to past studies on juvenile
       animals.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Animal  Animals, Newborn  Antigens, CD  Antigens, Viral/BLOOD  Disease
       Models, Animal  Female  Human  HIV Infections/ETIOLOGY  Infant, Newborn
       Leukocyte Count  Macaca mulatta  Male  Simian Acquired Immunodeficiency
       Syndrome/*ETIOLOGY/IMMUNOLOGY/  PATHOLOGY  Support, U.S. Gov't, P.H.S.
       SIV/IMMUNOLOGY/*PATHOGENICITY  Time Factors  T4 Lymphocytes/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).