Document 0340
 DOCN  M9440340
 TI    Association of interleukin-6 in the pathogenesis of acutely fatal
       SIVsmm/PBj-14 in pigtailed macaques.
 DT    9404
 AU    Birx DL; Lewis MG; Vahey M; Tencer K; Zack PM; Brown CR; Jahrling PB;
       Tosato G; Burke D; Redfield R; Department of Retroviral Research, Walter
       Reed Army Institute of; Research, Rockville, Maryland 20850.
 SO    AIDS Res Hum Retroviruses. 1993 Nov;9(11):1123-9. Unique Identifier :
       AIDSLINE MED/94145747
 AB    Infection with a variant of simian immunodeficiency virus
       (SIVsmm/PBj-14) causes death in juvenile pigtailed macaques within 8
       days of infection. The primary pathology is localized to the lymphoid
       tissues of the gut and spleen. Although the virus is present, the
       lesions are most consistent with acute reactive inflammation. We studied
       the serum and tissues for evidence of acute cytokine production often
       associated with acute inflammation. One factor, IL-6, was found to be
       significantly increased (> 1000-fold) over all other measured cytokines
       in all the pigtailed macaques who died acutely. Increased levels of IL-6
       were found both in the serum and in the inflamed tissues. mRNA for IL-6
       was found in the tissues with the highest protein levels of IL-6. The
       marked increase in IL-6 and IL-6 mRNA correlated with the virus levels
       in the tissues and serum as determined by viral isolation,
       immunohistochemistry, and Northern blot analysis. These findings suggest
       that the underlying pathogenesis of primary tissue damage, necrosis, and
       death by PBj-14 is the induction of cytokine production. Although the
       presence of the virus may be critical for the initiation of these
       events, the intense inflammatory reaction is associated with the cause
       of death.
 DE    Animal  Female  Interleukin-6/*BIOSYNTHESIS/BLOOD/GENETICS  Macaca
       nemestrina  Microscopy, Electron  RNA, Messenger/GENETICS/METABOLISM
       Simian Acquired Immunodeficiency Syndrome/*ETIOLOGY/IMMUNOLOGY/
       MICROBIOLOGY  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't,
       P.H.S.  SIV/IMMUNOLOGY/*PATHOGENICITY/ULTRASTRUCTURE  Time Factors
       Viremia/ETIOLOGY/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).