Document 0355
 DOCN  M9440355
 TI    [Ultrastructural study of azidothymidine-induced melanoderma in an AIDS
       patient]
 DT    9404
 AU    Hermanns-Le T; Gerardy-Goffin F; Giet-Lesuisse M; Pierard GE; Service de
       Dermatopathologie, CHU du Sart Tilman, Universite de; Liege.
 SO    Ann Pathol. 1993;13(5):328-31. Unique Identifier : AIDSLINE MED/94145506
 AB    We report an ultrastructural study of azidothymidine-induced
       melanoderma. The hyperpigmentation is linked to the presence of numerous
       single melanosomes and polymelanosomes in keratinocytes at all levels of
       the epidermis, and in dermal Factor XIIIa-positive dendrocytes. Such
       observation suggests an increased melanogenesis in melanocytes
       associated to a defect in the degradation of melanosomes normally
       occurring during epidermal maturation.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*DRUG THERAPY  Adult
       Case Report  English Abstract  Human  Male  Microscopy, Electron
       Pigmentation Disorders/CHEMICALLY INDUCED/*PATHOLOGY
       Skin/ULTRASTRUCTURE  Zidovudine/*ADVERSE EFFECTS  JOURNAL ARTICLE

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