Document 0363
 DOCN  M9440363
 TI    Role of human immunodeficiency virus infection in the pathogenesis of
       human papillomavirus-associated cervical neoplasia.
 DT    9404
 AU    Braun L; Department of Pathology and Laboratory Medicine, Brown;
       University, Providence, RI 02912.
 SO    Am J Pathol. 1994 Feb;144(2):209-14. Unique Identifier : AIDSLINE
       MED/94144670
 AB    Although many basic questions about the relationship between HIV and HPV
       infection remain unresolved, epidemiological studies have consistently
       shown a strong association between HIV infection and the development of
       HPV-related squamous intraepithelial neoplasia. This work indicates that
       HIV infection may promote the clinical manifestation of subclinical or
       latent HPV infection. Recent technical advances localizing virus DNA and
       gene products in situ will provide new avenues for investigation,
       allowing us to go beyond correlations and to clarify the mechanisms of
       interaction between the two viruses in individual patients. With
       improved antiretroviral therapy and prophylaxis for HIV-associated
       opportunistic infection and prolonged survival of women with HIV, HPV
       infection and its most serious consequence, cervical cancer, are likely
       to assume greater significance in the clinical management of
       HIV-infected women throughout the world. A better understanding of the
       role of HIV in promoting the clinical manifestation of HPV infection
       will be essential to the control of this disease.
 DE    Cervical Intraepithelial Neoplasia/*MICROBIOLOGY  Cervix
       Neoplasms/*MICROBIOLOGY  Female  Human  HIV Infections/*COMPLICATIONS
       HIV Seropositivity/COMPLICATIONS  *Papillomavirus, Human  Papovaviridae
       Infections/*COMPLICATIONS  Tumor Virus Infections/*COMPLICATIONS
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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