Document 0393
 DOCN  M9440393
 TI    Artificial protein vaccines with predetermined tertiary structure:
       application to anti-HIV-1 vaccine design.
 DT    9404
 AU    Eroshkin AM; Zhilkin PA; Shamin VV; Korolev S; Fedorov BB; Research
       Institute of Molecular Biology, NPO VECTOR, Koltsovo,; Novosibirsk
       Region, Russia.
 SO    Protein Eng. 1993 Nov;6(8):997-1001. Unique Identifier : AIDSLINE
       MED/94143356
 AB    A successful approach to the development of a safe and effective
       synthetic vaccine requires that different B and T cell epitopes of the
       infectious agent be included in the vaccine construction. In this paper
       we suggest a new approach to vaccine design in the form of an artificial
       protein with a predetermined tertiary structure (PTS vaccines). Based on
       B and T cell epitope properties, we substantiate the possible use for
       vaccine construction of one well-known protein spatial motif--the
       four-alpha-helix bundle. Antigenic determinants of cellular immunity
       (amphipathic alpha-helices) and humoral immunity (flexible hydrophilic
       loop regions) are used as blocks for vaccine design. General principles
       of PTS vaccine construction have been applied to anti-HIV-1 vaccine
       design.
 DE    Antigenic Determinants/*CHEMISTRY  AIDS Vaccines/*CHEMISTRY  Drug Design
       Gene Products, env/CHEMISTRY  Gene Products, gag/CHEMISTRY  HIV
       Antigens/*CHEMISTRY  HIV-1/*IMMUNOLOGY  Models, Molecular  Models,
       Theoretical  Protein Engineering  Protein Structure, Tertiary  Support,
       Non-U.S. Gov't  Vaccines, Synthetic/*CHEMISTRY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).