Document 0395
 DOCN  M9440395
 TI    [Effect of a filter system on measurement data and bacterial
       contamination in lung function studies]
 DT    9404
 AU    Strauss R; Wasser F; Mueller RL; Reim E; Wirtz P; Hahn EG; Siegfried W;
       Medizinische Klinik I mit Poliklinik,; Friedrich-Alexander-Universitat
       Erlangen-Nurnberg.
 SO    Pneumologie. 1993 Nov;47(11):626-30. Unique Identifier : AIDSLINE
       MED/94143320
 AB    80 measurements of the airway resistance of 20 patients did not yield
       any significant differences with or without using a bacterial filter
       (Pall PF 30) (p = 0.1213). Likewise, lung function tests conducted in 61
       further patients did not reveal any relevant changes caused by
       introducing the filter, in respect of the lung function parameters VKin,
       FEV1, PEF, FEF25, FEF50, FEF75 and TLCO. In these studies the flow
       receptors were examined for contamination by bacteria. The introduction
       of the bacterial filter reduced the total count of identified germs from
       108, 615 to 307, i.e. by 99.7 per cent, the greatest contamination being
       found in those parts that were close to the patient (57.6% with filter,
       97.1% without filter). Germs of the resident flora of the mouth and
       pharynx were identified, and occasionally also potential infectious
       agents such as staphylococcus aureus and streptococcus pneumoniae. The
       use of a filter system results in a marked decrease in the exposition to
       germs in lung function tests, without exercising any adverse effect on
       the measurement data (cross-contamination risk: 0.00078%). This is also
       achieved--albeit to a lesser extent--by changing those parts of the flow
       receptor that are close to the patient (cross-contamination risk:
       0.0841%). Hence, the use of a filter system appears particularly
       meaningful in patients with considerable immunodeficiency (advanced
       stages of HIV infection).
 DE    Airway Resistance/*PHYSIOLOGY  *Colony Count, Microbial  English
       Abstract  Equipment Contamination/*PREVENTION & CONTROL
       Filtration/*INSTRUMENTATION  Human  Lung Diseases,
       Obstructive/MICROBIOLOGY/PHYSIOPATHOLOGY  Lung Volume
       Measurements/*INSTRUMENTATION  Mouth/MICROBIOLOGY  Plethysmography,
       Whole Body/*INSTRUMENTATION  Reference Values  Staphylococcus
       aureus/ISOLATION & PURIF  Streptococcus pneumoniae/ISOLATION & PURIF
       JOURNAL ARTICLE

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