Document 0399
 DOCN  M9440399
 TI    [Are immunomodulators capable to improve the activity of nucleoside
       antiretroviral agents?]
 DT    9404
 AU    Sinet M; Pocidalo JJ; Unite INSERM U 13, Paris, France.
 SO    Pathol Biol (Paris). 1993 Oct;41(8 Pt 2):794-8. Unique Identifier :
       AIDSLINE MED/94143075
 AB    Synthetic polyribonucleotides stimulate cells to produce interferons and
       other cytokines and increase both humoral and cell-mediated immunity.
       The polynucleotide complexes affect host defense system and may have
       antiviral properties. Studies in animal models of experimental viral
       infection may therefore be performed to define a possible strategy for
       their use in human disease. Antiviral properties of polyribonucleotides
       have been demonstrated in animals, especially in murine models of
       retroviral infection. In the early treatment of Friend virus infection,
       the antiretroviral effect of zidovudine is enhanced by combination with
       poly I poly C or poly A poly U. Polyribonucleotides also enhance the
       inhibitory effect of zidovudine on HIV replication in lymphocyte T or
       macrophage cultures. Therefore this class of compounds could be used in
       combination with antiviral agents in the treatment of HIV infection,
       especially when they induce no significant toxicity as it is the case
       for poly A poly U.
 DE    Adjuvants, Immunologic/*PHARMACOLOGY  Animal  Antiviral
       Agents/PHARMACOLOGY  Drug Combinations  Drug Synergism  English Abstract
       Friend Virus/DRUG EFFECTS  Human  HIV Infections/THERAPY  HIV-1/*DRUG
       EFFECTS  In Vitro  Interferon-alpha/PHARMACOLOGY/THERAPEUTIC USE  Mice
       Poly A-U/*PHARMACOLOGY  Poly I-C/*PHARMACOLOGY  Poly U/*PHARMACOLOGY
       Zidovudine/*PHARMACOLOGY/THERAPEUTIC USE  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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