Document 0402
 DOCN  M9440402
 TI    [Role of cytokines in the regulation of HIV expression]
 DT    9404
 AU    Molina JM; Service des Maladies Infectieuses et Tropicales, Hopital;
       Saint-Louis, Paris.
 SO    Pathol Biol (Paris). 1993 Oct;41(8 Pt 2):777-80. Unique Identifier :
       AIDSLINE MED/94143072
 AB    The cytokine network, which is involved in the regulation of normal
       immune responses, may play a role in the pathogenesis of human
       immunodeficiency virus (HIV) infection, by altering the replication of
       HIV in target cells. In vitro data, suggest that certain cytokines like
       tumor necrosis factor alpha (TNF alpha) granulocyte-macrophage
       colony-stimulating factor (GM-CSF) and interleukin-6 (IL-6) could
       up-regulate HIV expression in T-cells and macrophages. Other cytokines
       like alpha interferon, are potent inhibitors of HIV replication.
       Surprisingly, the macrophage and the T-lymphocyte, the main source of
       cytokines in the body, do not produce any of these cytokines following
       HIV infection. B-lymphocytes however, spontaneously release TNF alpha
       and IL-6, that might enhance HIV replication in nearby monocytes and
       T-lymphocytes. This situation may occur in lymph nodes, a major
       reservoir of HIV.
 DE    B-Lymphocytes/METABOLISM  Cytokines/*METABOLISM  English Abstract
       Granulocyte-Macrophage Colony-Stimulating Factor/*PHARMACOLOGY  Human
       HIV Infections/MICROBIOLOGY/*PHYSIOPATHOLOGY  HIV-1/*DRUG EFFECTS/GROWTH
       & DEVELOPMENT  Interferon-alpha/PHARMACOLOGY
       Interleukin-6/BIOSYNTHESIS/*PHARMACOLOGY  Macrophages/MICROBIOLOGY
       Stimulation, Chemical  T-Lymphocytes/MICROBIOLOGY  Tumor Necrosis
       Factor/BIOSYNTHESIS/*PHARMACOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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