Document 0403
 DOCN  M9440403
 TI    [Antiviral chemotherapy: mechanisms of action, evaluation of activity,
       resistance and future developments]
 DT    9404
 AU    Agut H; Fillet AM; Huraux JM; Laboratoire de Bacteriologie-Virologie,
       CERVI, Hospitalier; Pitie-Salpetriere, Paris, France.
 SO    Pathol Biol (Paris). 1993 Oct;41(8 Pt 2):770-6. Unique Identifier :
       AIDSLINE MED/94143071
 AB    Antiviral chemotherapy is based on the selective inhibition of
       intracellular virus multiplication. Inhibitors of viral DNA polymerases
       perfectly exemplifies this mode of action. In spite of their
       selectivity, some of these drugs are cytotoxic and all remain
       unefficient against latent viruses. Evaluation of antiviral activity
       requires in vitro sensitivity tests, in vivo studies on animals and
       virological analyses during clinical trials. This evaluation needs well
       standardized assays. The emergence of in vitro resistance reflects the
       occurrence of mutations regarding target enzymes. Clinical significance
       of antiviral drug resistance needs to be assessed in many circumstances,
       even if its association with immunodeficiency often leads to a clear
       therapeutic failure. Further developments will include the synthesis of
       novel inhibitors, study of drug associations and improvement of
       virological diagnosis techniques relevant to therapy.
 DE    Acyclovir/PHARMACOLOGY/THERAPEUTIC USE  Animal  Antiviral
       Agents/*PHARMACOLOGY/THERAPEUTIC USE  Drug Resistance, Microbial  DNA
       Polymerases/*METABOLISM  English Abstract  Human  HIV Infections/*DRUG
       THERAPY  Immune Tolerance  In Vitro  Thymidine Kinase/METABOLISM
       Viruses/*DRUG EFFECTS/METABOLISM  Zidovudine/PHARMACOLOGY/THERAPEUTIC
       USE  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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