Document 0423
 DOCN  M9440423
 TI    Rheumatic manifestations in human immunodeficiency virus positive and
       negative individuals: a study of 2 populations with similar risk
       factors.
 DT    9404
 AU    Medina-Rodriguez F; Guzman C; Jara LJ; Hermida C; Alboukrek D; Cervera
       H; Miranda JM; Fraga A; Rheumatic Diseases Unit, Hospital de
       Especialidades, Mexico City,; Mexico.
 SO    J Rheumatol. 1993 Nov;20(11):1880-4. Unique Identifier : AIDSLINE
       MED/94141789
 AB    OBJECTIVE. Assess the impact of human immunodeficiency virus (HIV)
       infection on the onset of rheumatic manifestations in HIV+ patients, and
       to compare them with a control HIV- group with similar risk factors.
       METHODS. We prospectively studied 74 consecutive HIV+ patients, looking
       for clinical and laboratory findings of rheumatic manifestations and
       compared them with 72 control subjects with similar risk factors for HIV
       who tested negative for HIV. RESULTS. Rheumatic manifestations were more
       frequently observed in the HIV+ group than the HIV-group (p < 0.001):
       Arthralgias were found in 34 (45%), arthritis in 8 (10%), and Reiter's
       syndrome in 6 (8%). Laboratory findings revealed rheumatoid factor in 16
       (21%) HIV+ vs 2 (2%) in HIV-, antinuclear antibodies in 13 (17%) HIV+ vs
       0 in HIV-, IgG anticardiolipin antibodies in 70 (94%) HIV+ vs 7 (9%) in
       HIV- (p < 0.001). Hyperuricemia was found in 31 HIV+ patients (41%), and
       hypouricemia in 4 (5%), compared with none in the HIV- group (p <
       0.0001). Neoplasia were identified in 13 HIV+ patients, in 7 associated
       with hyperuricemia and 3 with hypouricemia. Of interest, 2 patients had
       urate abnormalities before the diagnosis of neoplasia. CONCLUSIONS. Our
       study suggests that rheumatic manifestations are more prevalent in HIV+
       patients. In advanced HIV infection, hypo and hyperuricemia may be
       considered markers of neoplasia.
 DE    Adult  Antibodies, Anticardiolipin/BLOOD  Antibodies, Antinuclear/BLOOD
       Comparative Study  Female  Human  HIV Seronegativity/PHYSIOLOGY  HIV
       Seropositivity/*COMPLICATIONS/*EPIDEMIOLOGY  Male  Mexico/EPIDEMIOLOGY
       Middle Age  Predictive Value of Tests  Prevalence  Prospective Studies
       Rheumatic Diseases/BLOOD/*COMPLICATIONS/*EPIDEMIOLOGY  Rheumatoid
       Factor/BLOOD  Risk Factors  Uric Acid/BLOOD  JOURNAL ARTICLE

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