Document 0432
 DOCN  M9440432
 TI    Blood in saliva of patients with acquired immunodeficiency syndrome:
       possible implication in sexual transmission of the disease.
 DT    9404
 AU    Piazza M; Chirianni A; Picciotto L; Cataldo PT; Borgia G; Orlando R;
       Institute of Infectious Diseases, University of Naples 2nd School; of
       Medicine, Italy.
 SO    J Med Virol. 1994 Jan;42(1):38-41. Unique Identifier : AIDSLINE
       MED/94141477
 AB    The presence and concentration of haemoglobin in saliva of anti-human
       immunodeficiency virus (HIV) positive subjects, anti-HIV-negative
       subjects at high risk of infection, and healthy controls were studied.
       One hundred eighty-eight subjects were anti-HIV-positive intravenous
       drug abusers (IVDA), 22 were anti-HIV-positive homosexual men, 23 were
       anti-HIV-positive heterosexual contacts, 132 were anti-HIV-negative
       IVDA, 35 were anti-HIV-negative homosexual men, and 154 were healthy
       controls. Two milliliters of saliva was collected in the morning before
       brushing teeth, and the presence and the concentration of haemoglobin
       were determined. Based on hemoglobin, the data show that the
       anti-HIV-positive IVDA have the highest tendency to bleeding. The
       difference between this group with respect to anti-HIV-negative IVDA (P
       < 0.05) and compared with healthy controls (P < 0.01) is statistically
       significant. This is also true of anti-HIV-positive heterosexual
       contacts with respect to healthy controls (P < 0.01). Our data show that
       all at-risk groups, both anti-HIV positive and anti-HIV negative, have
       higher haemoglobin concentration than the control group; this difference
       reaches statistical significance only between anti-HIV-positive IVDA and
       controls (P < 0.01). The concentration of haemoglobin is significantly
       higher in subjects with CD4+ lymphocytes < 200/mm3 compared to subjects
       with CD4+ lymphocytes > 200/mm3 (P < 0.01), in subjects with
       AIDS-related complex (ARC)/AIDS compared to asymptomatic/PGL subjects (P
       < 0.01), and in subjects with stomatitis compared to subjects without
       stomatitis (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adolescence  Adult  *Blood  Female  Hemoglobins/*ANALYSIS  Homosexuality
       Human  HIV Infections/*TRANSMISSION  HIV Seronegativity  HIV
       Seropositivity/*BLOOD  Male  Middle Age  Risk Factors  *Saliva/CHEMISTRY
       Stomatitis  Substance Abuse, Intravenous  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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