Document 0466
 DOCN  M9440466
 TI    Serum measurements of soluble CD23 in HIV infection.
 DT    9404
 AU    Bansal AS; Pumphrey RS; Mandal BK; Khoo SH; Wilson PB; Regional
       Immunology Service Manchester Central Hospital.
 SO    Immunology. 1993 Dec;80(4):652-3. Unique Identifier : AIDSLINE
       MED/94140421
 AB    A gradual reduction in cell-mediated immunity is thought to occur with
       the progression of human immunodeficiency virus (HIV) infection. This
       suggests a selective attrition of the Th1 subset. The regulation of the
       soluble form of the low-affinity receptor for IgE (sCD23) by the
       opposing actions of interleukin-4 (IL-4) and interferon-gamma
       (IFN-gamma) allows the assessment of the overall balance of Th1 to Th2
       activity in a given disease. In order to investigate this further we
       employed an enhanced chemiluminescent ELISA to analyse serum levels of
       sCD23 in male subjects with and without HIV infection. Serum levels of
       sCD23 were similar in 34 HIV seronegative homosexuals, 39 homosexuals
       with asymptomatic HIV infection, 27 homosexuals with acquired immune
       deficiency syndrome (AIDS) and 20 healthy controls. This suggests that
       HIV has no predilection for either the Th1 or Th2 subsets of CD4 T
       cells.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Adult  Human  HIV
       Infections/*IMMUNOLOGY  HIV Seronegativity/IMMUNOLOGY  Male  Receptors,
       IgE/*ANALYSIS  Solubility  T-Lymphocyte Subsets/IMMUNOLOGY  T4
       Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE

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