Document 0472
 DOCN  M9440472
 TI    The origin of human immunodeficiency virus type-1 rev gene. An
       evolutionary hypothesis.
 DT    9404
 AU    Kubota S; Oroszlan S; Hatanaka M; Laboratory of Molecular Virology and
       Carcinogenesis,; NCI-Frederick Cancer Research and Development Center,
       MD; 21702-1201.
 SO    FEBS Lett. 1994 Jan 31;338(2):118-21. Unique Identifier : AIDSLINE
       MED/94139907
 AB    The Rev protein of human immunodeficiency virus type-1 is an RNA-binding
       posttranscriptional transregulator encoded by an accessory gene that is
       distinct from retroviral oncogenes and whose origin is unclear. We
       hypothesize that the rev gene was generated by duplication of a viral
       RNA segment having a secondary-structure that evolved into the
       Rev-responsive element (RRE). This hypothesis is based on the following
       findings. First, accumulated data on functional mapping of Rev, Tat, and
       the transmembrane protein of Env suggested that the major coding exon of
       rev should have been inserted into the transmembrane region of env
       during the course of its evolution. Experiments with equine infectious
       anemia virus, another complex retrovirus, also indicate that a large
       portion of rev is located within the dispensable transmembrane region of
       env. Second, base usage analysis suggests the same origin for rev and
       RRE. Our hypothesis may provide a new insight into the evolutionary
       aspect of RNA-binding transactivators.
 DE    Base Sequence  DNA, Viral/CHEMISTRY  *Evolution  *Genes, rev
       HIV-1/*GENETICS  Models, Biological  Molecular Sequence Data  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

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