Document 0483
 DOCN  M9440483
 TI    Bronchoalveolar lavage fluid profiles in sarcoidosis, tuberculosis, and
       non-Hodgkin's and Hodgkin's disease. An evaluation of differences.
 DT    9404
 AU    Drent M; Wagenaar SS; Mulder PH; van Velzen-Blad H; Diamant M; van den
       Bosch JM; Department of Pulmonary Diseases, St. Antonius Hospital,;
       Nieuwegein, The Netherlands.
 SO    Chest. 1994 Feb;105(2):514-9. Unique Identifier : AIDSLINE MED/94139413
 AB    The aim of this study was to identify characteristic features in
       bronchoalveolar lavage fluid (BALF) samples of patients with
       tuberculosis, non-Hodgkin's or Hodgkin's disease and to investigate
       whether these differences facilitate the distinction of those disorders
       from sarcoidosis presenting with a similar clinical picture. Nonsmoker
       patients with histologically verified sarcoidosis (n = 29), tuberculosis
       (n = 6) proven by positive culture, non-Hodgkin's disease, (n = 6) or
       Hodgkin's disease (n = 7), both histologically verified, were
       investigated by BAL. A control group consisted of subjects without any
       pulmonary history. The presence of CD4+ and CD8+ T lymphocytes, as well
       as the CD4/CD8 ratio in BALF, aided in the differentiation between the
       various groups. Patients with malignant lymphomas had the lowest CD4/CD8
       ratio in BALF, as well as in peripheral blood, and occasionally, plasma
       cells were present in BALF samples. The most important feature of BALF
       analysis in tuberculosis was detection of the causal microbial agent. In
       conclusion, although malignant lymphomas and tuberculosis require
       histologic evaluation and a positive culture, respectively, for
       diagnosis, BALF analysis may be of additional value in distinguishing
       those disorders from sarcoidosis.
 DE    Adolescence  Adult  Aged  *Bronchoalveolar Lavage
       Fluid/CHEMISTRY/CYTOLOGY/IMMUNOLOGY  CD4-CD8 Ratio  Diagnosis,
       Differential  Female  Hodgkin's Disease/*DIAGNOSIS/IMMUNOLOGY/PATHOLOGY
       Human  IgG/ANALYSIS  IgM/ANALYSIS  Immunoglobulins, kappa-Chain/ANALYSIS
       Immunoglobulins, lambda-Chain/ANALYSIS  Lung
       Diseases/*DIAGNOSIS/IMMUNOLOGY/PATHOLOGY  Lung
       Neoplasms/*DIAGNOSIS/IMMUNOLOGY/PATHOLOGY  Lymphoma,
       Non-Hodgkin's/*DIAGNOSIS/IMMUNOLOGY/PATHOLOGY  Male  Middle Age
       Sarcoidosis/*DIAGNOSIS/IMMUNOLOGY/PATHOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes, Suppressor-Effector/PATHOLOGY  Tuberculosis,
       Pulmonary/*DIAGNOSIS/IMMUNOLOGY/PATHOLOGY  T4 Lymphocytes/PATHOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).