Document 0535
 DOCN  M9440535
 TI    Treatment of cryptosporidial diarrhea in an AIDS patient with
       paromomycin.
 DT    9404
 AU    Danziger LH; Kanyok TP; Novak RM; Department of Pharmacy Practice,
       Colleges of Pharmacy and; Medicine, University of Illinois at Chicago
       60612.
 SO    Ann Pharmacother. 1993 Dec;27(12):1460-2. Unique Identifier : AIDSLINE
       MED/94138128
 AB    OBJECTIVE: To report a case of diarrhea caused by Cryptosporidium in an
       AIDS patients which was successfully treated with paromomycin. CASE
       SUMMARY: An AIDS patient with a 12-month history of cryptosporidial
       diarrhea unresponsive to other treatment measures was treated with
       paromomycin 500 mg q6h for 14 days. Before initiating therapy, the
       patient was experiencing, on average, 20 bowel movements per day and had
       lost more than 25 kg. After therapy was initiated, the number of bowel
       movements dropped to 1-2 per day and the patient began to gain weight.
       The diarrhea recurred when therapy was discontinued. After retreatment
       for 14 days with paromomycin 500 mg q6h, the diarrhea stopped. The
       patient has not had a recurrence of Cryptosporidium diarrhea, stool
       cultures remain negative for Cryptosporidium oocysts, and the patient
       has regained most of the weight. DISCUSSION: Literature concerning the
       use of paromomycin for the treatment of cryptosporidiosis is discussed.
       A treatment algorithm for the management of cryptosporidiosis in AIDS
       patients is presented. CONCLUSIONS: We believe that we have presented a
       clear example of a case in which paromomycin was effective in treating
       and eradicating intestinal cryptosporidiosis in an AIDS patient.
       Paromomycin is the most effective agent available to date for the
       treatment of this devastating complication of AIDS.
 DE    Adult  Animal  AIDS-Related Opportunistic Infections/*DRUG THERAPY  Case
       Report  Cryptosporidiosis/*DRUG THERAPY  *Cryptosporidium parvum
       Diarrhea/*DRUG THERAPY  Feces/PARASITOLOGY  Human  Male
       Paromomycin/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Recurrence
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).