Document 0560
 DOCN  M9440560
 TI    Cutaneous sarcoid-like granulomas in primary immunodeficiency disorders.
 DT    9404
 AU    Levine TS; Price AB; Boyle S; Webster AD; Department of Cellular
       Pathology, Northwick Park Hospital and; Clinical Research Centre,
       Harrow, Middlesex, U.K.
 SO    Br J Dermatol. 1994 Jan;130(1):118-20. Unique Identifier : AIDSLINE
       MED/94137574
 AB    We report the occurrence of cutaneous sarcoid-like granulomas in one
       patient with common variable immunodeficiency and another with 'thymoma
       and hypogammaglobulinaemia'. To our knowledge, this is the first time
       that such skin lesions have been described in patients with primary
       immunodeficiency. These granulomas may be attributed to a combination of
       interleukin-2 deficiency and a profound CD4 lymphopenia. The lesions are
       similar to the non-infectious 'papular eruption' associated with human
       immunodeficiency virus infection, and might reflect a common pathogenic
       mechanism.
 DE    Adult  Agammaglobulinemia/COMPLICATIONS  Case Report  Common Variable
       Immunodeficiency/*COMPLICATIONS/PATHOLOGY  Female
       Granuloma/*COMPLICATIONS/PATHOLOGY  Human  Middle Age  Skin/PATHOLOGY
       Skin Diseases/*COMPLICATIONS/PATHOLOGY  Thymoma/COMPLICATIONS  Thymus
       Neoplasms/COMPLICATIONS  JOURNAL ARTICLE

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