Document 0596
 DOCN  M9440596
 TI    [A new variant of the simian T-lymphotropic retrovirus type I (STLV-IF)
       in the Sukhumi colony of hamadryas baboons]
 DT    9404
 AU    Chikobaeva MG; Schatzl H; Rose D; Bush U; Iakovleva LA; Deinhardt F;
       Helm K; Lapin BA
 SO    Vopr Virusol. 1993 Nov-Dec;38(6):249-53. Unique Identifier : AIDSLINE
       MED/94135953
 AB    Polymerase chain reaction (PCR) was developed for the detection of
       simian T-lymphotropic virus type 1 (STLV-1) infection of P. hamadryas
       and direct sequencing using oligo-nucleotide primer pairs specific for
       the tax and env regions of the related human T-lymphotropic virus type 1
       (HTLV-1). Excellent specificity was shown in the detection of STLV-1
       provirus in infected baboons by PCR using HTLV-1-derived primers. The
       nucleotide sequences of env 467bp and tax 159bp of the proviral genome
       (env position 5700-6137, tax position 7373-7498 HTLV-1, according to
       Seiki et al., 1983) derived from STLV-1-infected P. hamadryas were
       analysed using PCR and direct sequencing techniques. Two STLV-1 isolates
       from different sources (Sukhumi main-SuTLV-1 and forest stocks-STLV-1F)
       were compared. Two variants of STLV-1 among P. hamadryas with different
       level of homology to HTLV-1 were wound (83.8% and 95.2%, respectively).
       A possible role of nucleotide changes in env and tax sequenced fragments
       and oncogenicity of STLV-1 variants is discussed.
 DE    Animal  Base Sequence  Comparative Study  DNA, Viral/GENETICS/ISOLATION
       & PURIF  English Abstract  Georgia (Republic)  HTLV
       Infections/MICROBIOLOGY/VETERINARY  Lymph Nodes/MICROBIOLOGY
       Lymphocytes/MICROBIOLOGY  Molecular Sequence Data  Papio/*MICROBIOLOGY
       Polymerase Chain Reaction  Proviruses/GENETICS  Sequence Analysis, DNA
       STLV/*GENETICS  Variation (Genetics)/*GENETICS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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