Document 0620
 DOCN  M9440620
 TI    [Lymphomas in immunocompromised hosts]
 DT    9404
 AU    Berger F; Delecluse HJ; Laboratoire d'anatomie pathologique, hopital
       Edouard-Herriot,; Lyon.
 SO    Rev Prat. 1993 Sep 1;43(13):1661-4. Unique Identifier : AIDSLINE
       MED/94135136
 AB    Congenital and acquired states of immunodeficiency are associated with
       an increased incidence of ill-defined lymphoproliferations. These are
       mainly B-cell, often extranodal, lymphoproliferations commonly
       associated with EBV. Their incidence is increasing with the rapid
       development of organ transplantation and spreading of the HIV infection.
       The association with EBV partly explains the pathogeny of these
       affections. This ubiquitous virus immortalizes B lymphocytes in vitro
       and is tumorigenic for new world primates. An EBV-specific cytotoxic
       T-cell memory prevents uncontrolled proliferation of infected B cells in
       normal subjects after the primary infection. The X-linked
       lymphoproliferative syndrome is a primary immunodeficiency characterized
       by an abnormal immune responsiveness to EBV, resulting in fatal
       infectious mononucleosis and malignant lymphoma. The severe
       immunosuppression present in transplanted patients allows EBV infected
       cells to proliferate, giving rise to a spectrum of lymphoproliferations.
       Reduction of immunosuppression alone is, in some cases, sufficient to
       produce tumor regression. The evolution of these affections is difficult
       to predict and requires a combined biological and clinical analysis, in
       order to evaluate the aggressivity of the tumor and the ability of the
       immune response of the host. HIV infected patients have an increased
       risk of developing Burkitt's lymphomas which are associated with EBV in
       50% of the cases. Patients with AIDS at an advanced stage, present
       immunoblastic large cell lymphomas associated with EBV, similar to the
       post-transplant lymphomas. Lymphoproliferations in immunodeficiencies
       constitute a model for evaluation of the interaction between EBV and the
       immune system.
 DE    Animal  English Abstract  Human  Immunocompromised Host/*IMMUNOLOGY
       Immunologic Deficiency Syndromes/CONGENITAL/*COMPLICATIONS  Lymphoma,
       AIDS-Related/IMMUNOLOGY  Lymphoma, Non-Hodgkin's/*ETIOLOGY
       Transplantation/ADVERSE EFFECTS  JOURNAL ARTICLE  REVIEW  REVIEW
       LITERATURE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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