Document 0624
 DOCN  M9440624
 TI    Effects of thymus humoral factor gamma-2 (THF gamma 2) on
       lymphohaematopoietic progenitor cells: an in vitro study.
 DT    9404
 AU    Calenda V; Silvy F; Chermann JC; INSERM Unite 322, Parc Scientifique et
       Technologique de Luminy,; Marseille, France.
 SO    Res Immunol. 1993 Jul-Sep;144(6-7):395-406. Unique Identifier : AIDSLINE
       MED/94134981
 AB    Thymus humoral factor gamma-2 (THF gamma 2), an immunomodulatory factor,
       was previously shown to exert a regulatory effect upon human
       haematopoietic development. In the present study, we were primarily
       interested in determining whether THF gamma 2 has an immunorestorative
       effect after HIV infection. Although no inhibition of viral production
       by T-cluster-forming cells and their mature progeny was observed, this
       thymus-derived compound prevented the dramatic decrease in CD4+ cells
       observed in cultures of immature T cells from normal bone marrow
       infected with HIV 1.
 DE    Antiviral Agents/*PHARMACOLOGY  Colony-Forming Units Assay  DNA,
       Viral/GENETICS/ISOLATION & PURIF  Hematopoiesis/DRUG EFFECTS
       Hematopoietic Stem Cells/*DRUG EFFECTS/IMMUNOLOGY/MICROBIOLOGY  Human
       HIV Infections/DRUG THERAPY/IMMUNOLOGY/MICROBIOLOGY  HIV-1/*DRUG
       EFFECTS/GENETICS/PHYSIOLOGY  In Vitro  Lymphocytes/DRUG
       EFFECTS/IMMUNOLOGY/MICROBIOLOGY  Macrophages/DRUG
       EFFECTS/IMMUNOLOGY/MICROBIOLOGY  Monocytes/DRUG
       EFFECTS/IMMUNOLOGY/MICROBIOLOGY  Oligopeptides/*PHARMACOLOGY  Phenotype
       Polymerase Chain Reaction  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets/DRUG EFFECTS/IMMUNOLOGY  Thymus Hormones/*PHARMACOLOGY  Virus
       Replication/DRUG EFFECTS  JOURNAL ARTICLE

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