Document 0630
 DOCN  M9440630
 TI    A human amphotropic retrovirus receptor is a second member of the gibbon
       ape leukemia virus receptor family.
 DT    9404
 AU    van Zeijl M; Johann SV; Closs E; Cunningham J; Eddy R; Shows TB; O'Hara
       B; Molecular Biology Research Section, American Cyanamid Company,; Pearl
       River, NY 10965.
 SO    Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1168-72. Unique Identifier :
       AIDSLINE GENBANK/L20852
 AB    Retrovirus infection is initiated by binding of the viral envelope
       glycoprotein to a cell-surface receptor. The envelope proteins of type C
       retroviruses of mammals demonstrate similarities in structural
       organization and protein sequence. These similarities suggest the
       possibility that retroviruses from different interference groups might
       use related proteins as receptors, despite the absence of any
       relationship between retrovirus receptors isolated to date. To
       investigate this possibility, we have identified a human cDNA clone
       encoding a protein closely related to the receptor for gibbon ape
       leukemia virus and have found that it functions as the receptor for the
       amphotropic group of murine retroviruses. Expression of this protein
       (GLVR-2) is likely to be a requirement for infection of human cells by
       amphotropic retroviral vectors for purposes of gene therapy.
 DE    Amino Acid Sequence  Animal  Carrier Proteins/*GENETICS  Cell Line
       Chromosome Mapping  Cloning, Molecular  Comparative Study  CHO Cells
       DNA, Complementary/GENETICS  Gene Expression  Genetic Vectors  Hamsters
       Human  Leukemia Virus, Gibbon Ape/*METABOLISM  Leukemia Viruses,
       Murine/METABOLISM  Membrane Proteins/*GENETICS  Mice  Molecular Sequence
       Data  Receptors, Virus/*GENETICS  Retroviridae/*METABOLISM  Sequence
       Homology, Amino Acid  3T3 Cells  JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).