Document 0687
 DOCN  M9440687
 TI    Predicting CD4 counts in HIV-infected Brazilian individuals: a model
       based on the World Health Organization staging system.
 DT    9404
 AU    Schechter M; Zajdenverg R; Machado LL; Pinto ME; Lima LA; Perez MA; AIDS
       Program, Hospital Universitario Clementino Fraga Filho,; Federal
       University of Rio de Janeiro, Brazil.
 SO    J Acquir Immune Defic Syndr. 1994 Feb;7(2):163-8. Unique Identifier :
       AIDSLINE MED/94133087
 AB    CD4 cell counts are one of the best available surrogate markers for
       disease progression; they are widely used laboratory parameters in
       clinical trials and commonly used indicators for the introduction of
       primary prophylaxis and antiretroviral therapy. However, measurement is
       too expensive to be done in most developing countries. The objective of
       this study was to derive a model for prediction of CD4 counts < 200
       cells/mm3 based on the proposed World Health Organization (WHO) staging
       system for HIV infection and widely available laboratory parameters. One
       hundred and six consecutive patients enrolled in a prospective cohort
       study who were not taking anti-HIV drugs or prophylaxis for
       opportunistic infections were included. Blood tests were performed
       within 72 h of the outpatient visit. Lymphocyte phenotyping was done by
       flow cytometry. Two models based on the WHO staging system, hematocrit
       and total lymphocyte counts, were developed. The two models had
       sensitivity > 90% and specificity > 83%. These results indicate that the
       combined use of simple clinical and laboratory parameters can predict
       CD4 counts < 200 cells/mm3 with high sensitivity and specificity.
       Similar studies should be conducted in other countries. Should our
       findings be confirmed, intervention strategies based on this model of
       potential universal applicability should be devised and validated.
 DE    Adult  Aged  Analysis of Variance  Brazil  Cohort Studies  Discriminant
       Analysis  Female  Flow Cytometry  Hematocrit  Human  HIV
       Infections/*IMMUNOLOGY  Leukocyte Count  Male  Middle Age  Models,
       Theoretical  Predictive Value of Tests  Prospective Studies  Sensitivity
       and Specificity  Support, Non-U.S. Gov't  *T4 Lymphocytes  World Health
       Organization  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).