Document 0689
 DOCN  M9440689
 TI    Fetal toxicity of zidovudine (azidothymidine) in Macaca nemestrina:
       preliminary observations.
 DT    9404
 AU    Ha JC; Nosbisch C; Conrad SH; Ruppenthal GC; Sackett GP; Abkowitz J;
       Unadkat JD; Regional Primate Research Center, University of Washington,;
       Seattle 98195.
 SO    J Acquir Immune Defic Syndr. 1994 Feb;7(2):154-7. Unique Identifier :
       AIDSLINE MED/94133085
 AB    The objective of this study was to determine the dam, fetal, and infant
       toxicity of zidovudine (AZT) administered to pigtailed macaques during
       pregnancy. Pregnant macaques were administered AZT (1.5 mg/kg/dose every
       4 h) or water via gastric catheter throughout pregnancy. AZT
       concentration and hematological changes were monitored in the dam, and
       fetal growth was monitored via ultrasound. Infant hematocrit was
       assessed at birth, and the neurological, perceptual, and motor
       development of the offspring were assessed for 9 to 10 months. Twelve
       pregnancies were brought to term. Mean plasma concentrations of AZT were
       comparable to those in human studies. Hemoglobin dropped significantly
       in pregnant dams and remained low, whereas platelets increased during
       treatment but returned to normal before the end of the study. There were
       no significant differences in any ultrasound measure of fetal growth,
       and AZT-exposed infants exhibited little behavioral delay or impairment.
       We predict no significant toxic effects of prenatal AZT exposure at this
       dosage in humans.
 DE    *Abnormalities, Drug-Induced  Animal  Behavior, Animal/DRUG EFFECTS
       Female  Fetal Development/*DRUG EFFECTS  Hematocrit
       Hemoglobins/ANALYSIS  Macaca nemestrina  Pregnancy  Support, U.S. Gov't,
       P.H.S.  Ultrasonography, Prenatal  Weight Gain/DRUG EFFECTS
       Zidovudine/PHARMACOKINETICS/*TOXICITY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).