Document 0694
 DOCN  M9440694
 TI    Proliferative response of CD4+ and CD8+ T cell subsets from Hispanics
       with HIV+ and AIDS: the superantigen hypothesis.
 DT    9404
 AU    Eylar EH; Rivera-Quinones C; Laroche HI; Yamamura Y; Ponce School of
       Medicine, Department of Biochemistry, Puerto; Rico.
 SO    J Acquir Immune Defic Syndr. 1994 Feb;7(2):124-8. Unique Identifier :
       AIDSLINE MED/94133080
 AB    It has been hypothesized that the progressive deletion of CD4+ T cells
       in the course of infection due to human immunodeficiency virus (HIV) may
       be mediated in part by interaction with a superantigen inherent in an
       HIV protein. Consequently, selective loss of CD4+ cells with a T cell
       receptor V beta-chain capable of interaction with superantigen would
       produce a CD4+ population less or totally unresponsive to superantigen
       such as staphylococcal enterotoxins B and A (SEB and SEA respectively),
       but not to other mitogens such as concanavalin A, anti-CD3 (OKT3), or
       pokeweed mitogen. We tested this hypothesis by comparing the
       proliferative response of SEB and SEA with the other mitogens for 25
       controls, 20 HIV+, and 15 donors with acquired immune deficiency
       syndrome (AIDS). We found that peripheral blood mononuclear cells, as
       well as the CD4+ and CD8+ subsets from both HIV+ and AIDS sources, the
       degree of suppression of mitogenesis for SEB and SEA was approximately
       equal to or less than that of the other mitogens. Moreover, suppression
       of HIV+ CD4+ and CD8+ T cell responses to SEB and SEA was equal (26%).
       If HIV superantigens exist, our data suggest that they are not
       responsible for the selective depletion of the CD4+ T cell subset as
       evaluated by SEB and SEA specificity.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Adolescence  Adult
       Antigens, CD8/ANALYSIS  Child  Enterotoxins/IMMUNOLOGY  Human  HIV
       Antigens/IMMUNOLOGY  HIV Seropositivity/*IMMUNOLOGY  Lymphocyte
       Transformation  Puerto Rico  Staphylococcus aureus/IMMUNOLOGY
       Superantigens/*IMMUNOLOGY  Support, U.S. Gov't, P.H.S.  T-Lymphocytes,
       Suppressor-Effector/*IMMUNOLOGY  T4 Lymphocytes/*IMMUNOLOGY  JOURNAL
       ARTICLE

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