Document 0705
 DOCN  M9440705
 TI    Inhibitors of HIV-1 reverse transcriptase and fidelity of in vitro DNA
       replication.
 DT    9404
 AU    Abbotts J; Wilson SH; Laboratory of Biochemistry, National Cancer
       Institute, National; Institutes of Health, Bethesda, Maryland 20892.
 SO    J Enzym Inhib. 1992;6(1):35-46. Unique Identifier : AIDSLINE
       MED/94132921
 AB    Mechanisms of the effects of the dTTP analogues
       3'-azido-3'-deoxythymidine 5'-triphosphate (AZTTP) and
       3'-amino-3'-deoxythymidine 5'-triphosphate (NH2 TTP) upon the HIV-1
       reverse transcriptase (RT) are discussed. These compounds block the RT
       in vitro and do so by different kinetic mechanisms. Infidelity of
       replication is a hallmark of the HIV-1 RT, and replication errors by the
       enzyme on RNA and DNA templates are discussed. The enzyme's infidelity
       has ramifications for inhibition: On the one hand, the propensity to
       produce mutations enhances the ability of the virus to escape inhibitors
       whereas on the other hand, the infidelity of the reverse transcriptase
       may allow the development of imaginative inhibitor strategies.
 DE    Dideoxynucleosides/PHARMACOLOGY  *DNA Replication  HIV-1/*ENZYMOLOGY
       Reverse Transcriptase/*ANTAGONISTS & INHIB  Support, U.S. Gov't, P.H.S.
       Thymine Nucleotides/*PHARMACOLOGY  Virus Replication
       Zidovudine/*ANALOGS & DERIVATIVES/PHARMACOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).