Document 0708
 DOCN  M9440708
 TI    Cytokine expression in the spinal cord lesions in HTLV-I-associated
       myelopathy.
 DT    9404
 AU    Umehara F; Izumo S; Ronquillo AT; Matsumuro K; Sato E; Osame M; Third
       Department of Internal Medicine, Faculty of Medicine,; Kagoshima
       University, Japan.
 SO    J Neuropathol Exp Neurol. 1994 Jan;53(1):72-7. Unique Identifier :
       AIDSLINE MED/94132842
 AB    Immunocytochemical staining of spinal cords from five autopsied patients
       with HTLV-I-associated myelopathy/tropical spastic paraparesis was
       performed using a panel of monoclonal or polyclonal antibodies reactive
       with interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor
       necrosis factor (TNF)-alpha, interferon (IFN)-alpha, IFN-beta, IFN-gamma
       and transforming growth factor (TGF)-beta. In the spinal cords of
       patients with a shorter duration of illness, IL-1 beta, TNF-alpha, and
       IFN-gamma were expressed on perivascular infiltrating macrophages,
       astrocytes and microglia in active-chronic inflammatory lesions. In
       striking contrast, we rarely noted cytokine expression except for
       IFN-gamma in inactive-chronic lesions of patients with longer durations.
       In situ expression of these cytokines on microglia and astrocytes, in
       addition to infiltrating mononuclear cells, suggests that glial cells
       participate in the inflammatory process, especially in active lesions.
       In addition, the cytokine expression was gradually downregulated along
       with duration of illness.
 DE    Aged  Animal  Antibodies  Antibodies, Monoclonal  Autopsy
       Cytokines/ANALYSIS/*METABOLISM  Female  Glial Fibrillary Acidic
       Protein/ANALYSIS  Human  IgG  Immunoenzyme Techniques
       Immunohistochemistry  Inflammation  Interferon Type II/ANALYSIS
       Interferon-alpha/ANALYSIS  Interferon-beta/ANALYSIS
       Interleukin-1/ANALYSIS  Interleukin-6/ANALYSIS  Male  Mice/IMMUNOLOGY
       Middle Age  Paraparesis, Tropical Spastic/*PATHOLOGY  Rabbits/IMMUNOLOGY
       Spinal Cord/*PATHOLOGY  Support, Non-U.S. Gov't  Transforming Growth
       Factor beta/ANALYSIS  Tumor Necrosis Factor/ANALYSIS  JOURNAL ARTICLE

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