Document 0710
 DOCN  M9440710
 TI    Acute diffuse leukoencephalitis in HIV-1 infection.
 DT    9404
 AU    Luer W; Gerhards J; Poser S; Weber T; Felgenhauer K; Department of
       Neurology, Georg-August University, Gottingen,; Germany.
 SO    J Neurol Neurosurg Psychiatry. 1994 Jan;57(1):105-7. Unique Identifier :
       AIDSLINE MED/94132807
 AB    The clinical, neuroradiological, and cerebrospinal fluid findings of a
       case with acute diffuse leukoencephalitis, a demyelinating disease
       associated with human immunodeficiency virus infection of the brain, is
       reported. The patient presented with acute tetraparesis as the primary
       manifestation of a previously symptom free HIV infection. Cerebrospinal
       fluid analysis showed enhanced inflammatory abnormalities with high
       concentrations of P24 antigen. MRI showed diffuse white matter
       hyper-intensities in both hemispheres. In the follow up over 22 months,
       the neurological deficits disappeared after antiretroviral treatment in
       good correlation with improvements in MRI as well as in inflammatory
       cerebrospinal fluid abnormalities.
 DE    Adult  AIDS Dementia Complex/*DIAGNOSIS/DRUG THERAPY/PATHOLOGY
       Brain/DRUG EFFECTS/*PATHOLOGY/RADIOGRAPHY  Case Report  Cerebrospinal
       Fluid/CHEMISTRY/IMMUNOLOGY  Female  Human  HIV Antibodies/IMMUNOLOGY
       HIV Core Protein p24/CEREBROSPINAL FLUID/IMMUNOLOGY  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Magnetic
       Resonance Imaging  Zidovudine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE
       JOURNAL ARTICLE

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