Document 0726
 DOCN  M9440726
 TI    Cytokine involvement in viral permissiveness and the progression of HIV
       disease.
 DT    9404
 AU    Butera ST; Retrovirus Diseases Branch, Centers for Disease Control and;
       Prevention, Atlanta, Georgia 30333.
 SO    J Cell Biochem. 1993 Dec;53(4):336-42. Unique Identifier : AIDSLINE
       MED/94132199
 AB    Many viruses have evolved novel means of exploiting host defense
       mechanisms for their own survival. This exploitation may be best
       exemplified by the interrelationships between certain viruses and the
       host cytokine networks. Many viruses, including the human
       immunodeficiency virus type-1 (HIV-1), rely on the liberation and
       cellular action of host immune cytokines to expand their host cell
       range, to regulate their cellular expression, and to maintain their
       dormant state until the proper extracellular conditions arise. As again
       exemplified by HIV-1, viruses may also take an active role regulating
       cytokine expression and cell surface cytokine receptors. Because the
       viral life cycle, and in particular the HIV-1 life cycle, is so
       intertwined with cytokine regulatory networks, these networks represent
       potential points for therapeutic intervention. As our understanding of
       cellular cytokine pathways involved in viral infection and replication
       continues to expand, so too will our ability to design rational
       anti-viral therapies to alter multiple steps along the viral life cycle.
 DE    Acquired Immunodeficiency Syndrome/*MICROBIOLOGY
       Cytokines/PHARMACOLOGY/*PHYSIOLOGY  Human  HIV-1/*PATHOGENICITY  Tumor
       Necrosis Factor/PHARMACOLOGY/PHYSIOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).