Document 0733
 DOCN  M9440733
 TI    Herpes simplex encephalitis: a diagnostic and therapeutic reapprisal.
 DT    9404
 AU    Satishchandra P; Nandini M; Shankar SK; Vasudevarao T; Ravi V; Shenoy
       PK; Chatterjee S; Jain S; Department of Neurology, National Institute of
       Mental Health &; Neuro Sciences (NIMHANS), Bangalore.
 SO    J Assoc Physicians India. 1993 May;41(5):277-8. Unique Identifier :
       AIDSLINE MED/94131875
 AB    Herpes Simplex Encephalitis (HSE) appears to be underdiagnosed in India,
       though viral encephalitides constitutes an important entity with
       significant morbidity. With an upsurge in AIDS, HSE may perhaps emerge
       as an important opportunistic infection in future. We discuss the
       clinical features and laboratory evaluation of nine cases of HSE seen in
       the last 12 years at our center. Diagnosis was established by brain
       biopsy in one, virological studies in six and at autopsy in three.
       Immunocytochemically viral antigens could be localized in 4
       biopsied/autopsied brain tissue and in CSF cells on a cytospin
       preparation in one. This has facilitated rapid diagnosis in our cases.
       Virus isolation was successful in two. Three subjects were treated with
       acyclovir and all survived with variable morbidity. Four patients
       expired and none of them had received any specific antiviral drugs.
       Rapid diagnosis and early treatment with acyclovir has been highlighted.
 DE    Acyclovir/THERAPEUTIC USE  Adult  Biopsy  Brain/MICROBIOLOGY/PATHOLOGY
       Electroencephalography  Encephalitis/*DIAGNOSIS/DRUG THERAPY  Female
       Herpes Simplex/*DIAGNOSIS/DRUG THERAPY  Human  Male  Middle Age
       Tomography, X-Ray Computed  JOURNAL ARTICLE

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