Document 0745
 DOCN  M9440745
 TI    Urinary tract infection in men with AIDS.
 DT    9404
 AU    De Pinho AM; Lopes GS; Ramos-Filho CF; Santos O da R; De Oliveira MP;
       Halpern M; Gouvea CA; Schechter M; Departamento de Medicina Preventiva,
       Hospital Universitario; Clementino Fraga Filho, Universidade Federal do
       Rio de Janeiro,; Brasil.
 SO    Genitourin Med. 1994 Feb;70(1):30-4. Unique Identifier : AIDSLINE
       MED/94131454
 AB    OBJECTIVE--To investigate whether bacteriuria and, specifically,
       symptomatic urinary tract infection (UTI) occur with increased frequency
       in men with HIV infection. METHODS--In this cross-sectional study we
       investigated three groups of men, aged from 18 to 50 years. Group A was
       composed of patients with a diagnosis of AIDS; Group B, of patients
       without HIV infection, and group C of patients with asymptomatic HIV
       infection. Patients with any known predisposing factor for UTI were
       excluded from the study. A clean-catch midstream urine sample was
       collected from each patient on the first day of hospital admission
       (groups A and B) or during a visit to the outpatient clinic (group C).
       Bacteriuria was diagnosed when > or = 100,000 colony forming units/ml,
       urine were grown. RESULTS--There were 415 patients, 151 in group A, 170
       in group B and 94 in group C. Bacteriuria was significantly more
       frequently in group A (20 cases, 13.3%) than in groups B (3 cases, 1.8%,
       p = 0.00007) and C (3 cases, 3.2%, p = 0.009). Ten cases of bacteriuria
       in group A (6.6%) were symptomatic while no case of symptomatic UTI was
       seen in groups B (p = 0.0004) and C (p = 0.008). The frequency of UTI in
       homosexual men with AIDS (7 cases, 6.7%) was not significantly different
       from that observed in men with AIDS who denied homosexuality (3 cases,
       6.5%). E coli was the predominant pathogen associated with UTI. Although
       adequate response to a two-week course of antibiotics was observed in
       most cases, an in-hospital mortality rate of 20% was found among AIDS
       patients with symptomatic UTI. CONCLUSIONS--In the present study, the
       frequency of bacteriuria and symptomatic UTI was found to be increased
       in men with AIDS. E coli was the predominant pathogen in these cases.
       These data suggest that symptomatic UTI may represent a relevant cause
       of morbidity for men with AIDS.
 DE    Adolescence  Adult  Antibiotics/THERAPEUTIC USE  AIDS-Related
       Opportunistic Infections/DRUG THERAPY/*EPIDEMIOLOGY  Bacteriuria/DRUG
       THERAPY/*EPIDEMIOLOGY  Cross-Sectional Studies  Homosexuality  Human
       Male  Middle Age  Prevalence  Support, Non-U.S. Gov't  Urinary Tract
       Infections/DRUG THERAPY/*EPIDEMIOLOGY  JOURNAL ARTICLE

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