Document 0764
 DOCN  M9440764
 TI    Differential suppression activity induced by paternal leukocyte
       immunization in habitual abortion.
 DT    9404
 AU    Behar E; Carp H; Livneh A; Gazit E; Tissue Typing Laboratory, Chaim
       Sheba Medical Center,; Tel-Hashomer, Israel.
 SO    Gynecol Obstet Invest. 1993;36(4):202-7. Unique Identifier : AIDSLINE
       MED/94131350
 AB    In order to investigate the possible role of suppressor cells in
       paternal leukocyte immunization to prevent recurrent miscarriages,
       peripheral blood lymphocytes from habitually aborting women before and
       after immunization were assessed. Immunization-induced suppressor
       activity as shown by (1) rise in CD8-positive cells and a decline in the
       CD4/CD8 ratio, (2) failure of cyclosporine A to inhibit the
       proliferation of phytohemagglutinin- and alloantigen-stimulated cells
       and (3) unresponsiveness to the immunizing spouses' antigen. These
       findings resembled those in normal pregnant women. Hence, paternal
       leukocyte immunization may induce specific and nonspecific T cell
       suppression which may induce the immune tolerance necessary to maintain
       pregnancy.
 DE    Abortion, Habitual/IMMUNOLOGY/*PREVENTION & CONTROL
       Cyclosporine/PHARMACOLOGY  CD4-CD8 Ratio  Female  Human  *Immunotherapy
       *Leukocyte Transfusion  Leukocytes, Mononuclear/DRUG EFFECTS/*IMMUNOLOGY
       Male  Pregnancy  T-Lymphocytes, Suppressor-Effector/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).