Document 0765
 DOCN  M9440765
 TI    Reactive oxygen species, chromosome mutation, and cancer: possible role
       of clastogenic factors in carcinogenesis.
 DT    9404
 AU    Emerit I; Centre National de la Recherche Scientifique, Paris, France.
 SO    Free Radic Biol Med. 1994 Jan;16(1):99-109. Unique Identifier : AIDSLINE
       MED/94131342
 AB    Superoxide radicals may induce genotoxic effects by indirect action
       mechanisms, implicating the formation of more long-lived, secondary
       clastogenic material called chromosome breakage factors or clastogenic
       factors (CF). CF are produced via the intermediacy of superoxide, and
       stimulate further superoxide production by competent cells. This results
       in a selfsustaining and longlasting process of clastogenesis, which may
       exceed the DNA repair system and ultimately lead to cancer. An increased
       cancer risk is indeed observed in conditions accompanied by CF
       formation. These include irradiated persons, asbestos workers, patients
       with chronic inflammatory diseases, HIV-infected persons, and the
       congenital breakage syndromes ataxia telangiectasia, Bloom's syndrome,
       and Fanconi's anemia. Because reactive oxygen species (ROS) are
       implicated in CF formation and CF action, antioxidants may be protective
       as anticlastogens and consequently as anticarcinogens. In persons at
       high risk because of their occupation, life style or place of residence,
       the presence of CF may represent an indication for chemoprevention of
       cancer by antioxidants. CF can be useful as biochemical markers and
       intermediate endpoints for the evaluation of promising drugs. They are
       therefore not only of interest as a mechanism by which ROS may exert
       genotoxic effects, but also have practical implications.
 DE    Animal  Human  *Mutagenesis  *Mutagens/METABOLISM/PHARMACOLOGY
       Neoplasms/*ETIOLOGY  *Reactive Oxygen Species  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).