Document 0769
 DOCN  M9440769
 TI    Oral hairy leukoplakia in a patient with ulcerative colitis.
 DT    9404
 AU    Fluckiger R; Laifer G; Itin P; Meyer B; Lang C; St. Claraspital Basel,
       Switzerland.
 SO    Gastroenterology. 1994 Feb;106(2):506-8. Unique Identifier : AIDSLINE
       MED/94131250
 AB    A 30-year-old man with ulcerative colitis developed oral hairy
       leukoplakia (OHL). Serological examination for human immunodeficiency
       virus (HIV)-1 and HIV-2 infection showed no abnormalities. Biopsy
       specimen of the lateral tongue showed ballooned prickle cells, and
       electron microscopy revealed herpes-type viruses. Immunologic
       investigation of the patient showed a marked decrease in T-helper cells
       as a result of immunosuppressive regimen. The present report appears to
       be the first well-documented case of OHL in an HIV-negative patient with
       ulcerative colitis. OHL may be a marker for severe immunosuppression but
       is not necessarily associated with HIV infection. Patients with
       iatrogenic immunosuppression should be monitored for OHL. Concerning the
       marked decrease in T-helper cells in this case, the presence of OHL may
       imply the examination of T-lymphocyte subsets in patients such as
       HIV-infected individuals or in organ transplant recipients.
 DE    Adult  Case Report  Colitis, Ulcerative/*COMPLICATIONS  Human  HIV
       Seronegativity  Immune Tolerance  Leukoplakia, Hairy/*ETIOLOGY  Male
       T-Lymphocyte Subsets/IMMUNOLOGY  JOURNAL ARTICLE

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