Document 0774
 DOCN  M9440774
 TI    V beta gene repertoires in T cells expanded in local self-healing and
       lethal systemic murine cutaneous leishmaniasis.
 DT    9404
 AU    Lohoff M; Steinert M; Weiss A; Rollinghoff M; Balderas RS;
       Theofilopoulos AN; Institut fur klinische Mikrobiologie, Erlangen, FRG.
 SO    Eur J Immunol. 1994 Feb;24(2):492-5. Unique Identifier : AIDSLINE
       MED/94130974
 AB    Inbred mice infected with Leishmania major promastigotes display two
       different courses of leishmaniasis: resistant strains develop
       self-healing local sores, while susceptible strains show progressive
       systemic disease with lethal outcome. Resistance predominantly
       correlates with the production of T helper type 1 (TH1) lymphokines and
       susceptibility with production of TH2-type lymphokines. Here, we
       analyzed whether this TH phenotype difference correlates with expression
       of particular T cell receptor V beta chains. Our results show that T
       cells expand strongly during infection in all groups of mice and
       invariantly express the same V beta gene families as prior to infection.
       Our data indicate that TH1 and TH2 cells use similar V beta gene
       families, and argue against the engagement of a restricted set of V beta
       by dominant determinants associated with L. major.
 DE    Animal  CD4-CD8 Ratio  Female  Gene Expression  Gene Rearrangement,
       beta-Chain T-Cell Antigen Receptor  Leishmania major/IMMUNOLOGY
       Leishmaniasis, Cutaneous/*IMMUNOLOGY  Mice  Mice, Inbred BALB C  Mice,
       Inbred C57BL  Receptors, Antigen, T-Cell, alpha-beta/*GENETICS  RNA,
       Messenger/GENETICS  Support, Non-U.S. Gov't  T4 Lymphocytes/*IMMUNOLOGY
       JOURNAL ARTICLE

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