Document 0778
 DOCN  M9440778
 TI    Age-related changes in human blood lymphocyte subpopulations. II.
       Varying kinetics of percentage and absolute count measurements.
 DT    9404
 AU    Hulstaert F; Hannet I; Deneys V; Munhyeshuli V; Reichert T; De Bruyere
       M; Strauss K; Becton Dickinson Immunocytometry Systems,
       Erembodegem-Aalst,; Belgium.
 SO    Clin Immunol Immunopathol. 1994 Feb;70(2):152-8. Unique Identifier :
       AIDSLINE MED/94130399
 AB    A reference range for lymphocyte populations, with particular emphasis
       on T lymphocyte subsets, was obtained for normal individuals covering
       age cohorts from birth through adulthood. This report confirms and
       extends findings from a developmental reference range published earlier
       (1). Absolute numbers of WBC, lymphocytes, and T, B, and NK subsets
       decline significantly during childhood. However, differences in the rate
       of decline of certain lymphocyte subsets leads to discordance between
       absolute numbers and percentages. Those lymphocyte subsets which decline
       less rapidly with age than the total lymphocyte count will show an
       increase in percentage, whereas those which decline more rapidly will
       show further declines in percentage values. T cell percentages were seen
       to increase over time whereas B cell percentages decline. Markers of
       immaturity such as CD45RA on CD4 cells and CD38 on CD8 cells declined in
       both percentages and absolute numbers. Activation markers, such as
       HLA-DR on CD8 cells and IL2-R on CD3 cells, increased in percentages
       with time but changed inconsistently in cell number from infancy to
       adulthood. These findings extend the lymphocyte references range to
       markers thought to be informative in various disease states, including
       HIV infection.
 DE    Adolescence  Adult  *Aging  Antigens, CD45/ANALYSIS  Antigens,
       CD8/ANALYSIS  Antigens, Differentiation, T-Lymphocyte/*ANALYSIS  Child
       Child, Preschool  Female  Human  Immunophenotyping  Infant  Infant,
       Newborn  Leukocyte Count  Male  Middle Age  T-Lymphocyte
       Subsets/*IMMUNOLOGY  T4 Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).