Document 0788
 DOCN  M9440788
 TI    Immune reconstitution following peripheral blood stem cell
       transplantation, autologous bone marrow transplantation and allogeneic
       bone marrow transplantation.
 DT    9404
 AU    Roberts MM; To LB; Gillis D; Mundy J; Rawling C; Ng K; Juttner CA;
       Haematology Department, Institute of Medical and Veterinary; Science,
       Adelaide, Australia.
 SO    Bone Marrow Transplant. 1993 Nov;12(5):469-75. Unique Identifier :
       AIDSLINE MED/94129521
 AB    The rate and pattern of recovery of total lymphocytes, T cell subsets, B
       cells and NK cells were compared for 12 months following recovery phase
       peripheral blood stem cell (PBSC) autotransplantation (n = 49),
       autologous (n = 7) and allogeneic BMT (n = 11). The PBSC group had a
       significantly faster recovery of total lymphocyte count, total T cells
       (CD3+ cells), CD8 cells and CD4 cells than the allogeneic BMT group. The
       pattern of earlier recovery of CD8 cells than CD4 cells was the same for
       each type of transplant. Reconstitution following autologous BMT was
       intermediate between PBSC and allogeneic BMT. Multivariate analysis
       identified type of transplant, number of mononuclear cells transplanted
       and conditioning regimen as significantly influencing immune recovery.
 DE    B-Lymphocyte Subsets/IMMUNOLOGY/PATHOLOGY
       B-Lymphocytes/IMMUNOLOGY/*PATHOLOGY  Blood Cells/IMMUNOLOGY/*PATHOLOGY
       *Blood Transfusion, Autologous  Bone Marrow Transplantation/*PATHOLOGY
       Cell Count  Comparative Study  CD4-CD8 Ratio  Hematopoietic Stem
       Cells/IMMUNOLOGY/*TRANSPLANTATION  Human  Killer Cells,
       Natural/IMMUNOLOGY/*PATHOLOGY  Multivariate Analysis  Support, Non-U.S.
       Gov't  T-Lymphocyte Subsets/IMMUNOLOGY/PATHOLOGY
       T-Lymphocytes/IMMUNOLOGY/*PATHOLOGY  Time Factors  Transplantation,
       Autologous  Transplantation, Homologous  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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