Document 0790
 DOCN  M9440790
 TI    Distribution of immunocompetent cells in oral Kaposi's sarcoma (AIDS).
 DT    9404
 AU    Tabata M; Langford A; Becker J; Reichart PA; Department of Oral and
       Maxillofacial Surgery, Kagoshima; University Dental School, Japan.
 SO    Eur J Cancer B Oral Oncol. 1993 Jul;29B(3):209-13. Unique Identifier :
       AIDSLINE MED/94129345
 AB    Fifteen biopsy specimens of oral AIDS-associated Kaposi's sarcoma (KS),
       19 biopsy specimens of uninvolved oral mucosa of HIV-seropositive
       patients (HIV+) and 22 biopsy specimens of oral mucosa of
       HIV-seronegative persons (HIV-) were analysed for the distribution of
       CD4+ and CD8+ lymphocytes and HLA-DR+ cells. The results were
       statistically evaluated. According to their clinical appearance KS were
       classified as flat lesions (n = 10) or exophytic tumours (n = 5). KS
       lesions of both clinical groups as well as uninvolved mucosa of HIV+
       patients revealed infiltration with CD4+ cells. In flat, patch-like KS
       there was a marked increase of CD8+ cells compared to HIV- mucosa, while
       their numbers decreased in later tumour stages. In both, flat and
       exophytic KS the number of HLA-DR+ cells was significantly higher than
       in uninvolved mucosa of HIV+ and HIV- persons. These findings may
       reflect the local influence of KS growth factors on the inflammatory
       reaction in the setting of systemic immunosuppression.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Analysis of Variance
       Antigens, CD4/ANALYSIS  Antigens, CD8/ANALYSIS  Antigens,
       Neoplasm/ANALYSIS  Comparative Study  CD4-CD8 Ratio  Human  HIV
       Seronegativity  HIV Seropositivity  HLA-DR Antigens/ANALYSIS  Mouth
       Mucosa/IMMUNOLOGY  Mouth Neoplasms/ETIOLOGY/*IMMUNOLOGY/PATHOLOGY
       Sarcoma, Kaposi's/ETIOLOGY/*IMMUNOLOGY/*PATHOLOGY  *T-Lymphocyte Subsets
       T4 Lymphocytes  JOURNAL ARTICLE

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