Document 0830
 DOCN  M9440830
 TI    Mood disorders in HIV infection: prevalence and risk factors in a
       nonepicenter of the AIDS epidemic.
 DT    9404
 AU    Perkins DO; Stern RA; Golden RN; Murphy C; Naftolowitz D; Evans DL;
       Department of Psychiatry, University of North Carolina School of;
       Medicine, Chapel Hill 27599-7160.
 SO    Am J Psychiatry. 1994 Feb;151(2):233-6. Unique Identifier : AIDSLINE
       MED/94127578
 AB    OBJECTIVE: The authors studied the lifetime, initial cross-sectional,
       and 6-month follow-up prevalence of mood disorders in asymptomatic
       HIV-infected and uninfected homosexual men who lived in an area with a
       low prevalence of HIV. They also determined the relationship between
       current major depression and potential depression risk factors. METHOD:
       Subjects included 98 asymptomatic HIV-infected and 71 uninfected
       homosexual men. Subjects underwent extensive clinical, psychiatric,
       neuropsychological, and laboratory evaluations. RESULTS: Similar
       proportions of HIV-infected and uninfected subjects reported a lifetime
       (29% and 45%, respectively), an initial current (8% and 3%), and a
       6-month follow-up (9% and 11%) history of major depressive disorder.
       Anxiety disorders were less common, with similar proportions of
       HIV-infected and uninfected subjects reporting a lifetime (7% and 13%,
       respectively), an initial current (3% and 7%), and a 6-month follow-up
       (2% and 5%) history of anxiety disorders. There were no differences in
       the severity of mood symptoms between HIV-infected and uninfected
       subjects. Current major depression at initial visit was significantly
       associated with lifetime history of major depression but not with
       neuropsychological function or vitamin B12 level. CONCLUSIONS: These
       findings are in agreement with previous studies of areas with a high
       prevalence of HIV. However, the proportion of subjects with mood
       disorders is high compared with general population studies. Both
       HIV-infected and uninfected homosexual men may be at high risk for major
       depression, especially if they have a past history of depression.
       Moreover, in the asymptomatic stage of HIV infection, major depression
       does not appear to be secondary to HIV central nervous system effects or
       low vitamin B12 levels.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY  Adult  Comorbidity
       Cross-Sectional Studies  Depressive Disorder/DIAGNOSIS/*EPIDEMIOLOGY
       Disease Outbreaks/STATISTICS & NUMER DATA  Follow-Up Studies
       *Homosexuality  Human  HIV Infections/*EPIDEMIOLOGY  Male  Mental
       Disorders/DIAGNOSIS/EPIDEMIOLOGY  Prevalence  Psychiatric Status Rating
       Scales  Risk Factors  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).