Document 0835
 DOCN  M9440835
 TI    Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or
       cell-free viral transmission.
 DT    9404
 AU    Bourinbaiar AS; Tan X; Nagorny R; Department of Pediatrics, NYU Medical
       Center, NY 10016.
 SO    Acta Virol (Praha). 1993 Aug;37(4):241-50. Unique Identifier : AIDSLINE
       MED/94127346
 AB    A single dose of coumarin derivatives, warfarin, 4-hydroxycoumarin and
       umbelliferone, added at the time of inoculation either by free virus or
       by contact with U1 monocytes exhibited a dose-dependent inhibitory
       effect on viral replication in target MOLT-4 lymphocytes observable even
       at 5 days post infection. In addition, marked decrease of HIV-1 gap p24
       release and reduction in reverse transcriptase activity was observed
       when chronically HIV-infected ACH-2 lymphocytes were treated with
       coumarins (ED50% range 10(-6)-10(-9) mol/l). However, the intracellular
       composition of HIV-1 core proteins in drug-exposed cells was not
       modified. Results suggest that although no complete inhibition of viral
       production has been observed in vitro this class of drugs may present
       potential interest as antiviral agents.
 DE    Cell-Free System  Coumarins/*PHARMACOLOGY  Human  HIV Core Protein
       p24/DRUG EFFECTS  HIV-1/*DRUG EFFECTS/PHYSIOLOGY/PATHOGENICITY
       Lymphocytes/MICROBIOLOGY  Transcription, Genetic/DRUG EFFECTS
       Umbelliferones/PHARMACOLOGY  Virus Replication/*DRUG EFFECTS
       Warfarin/PHARMACOLOGY  4-Hydroxycoumarins/PHARMACOLOGY  JOURNAL ARTICLE

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