Document 0836
 DOCN  M9440836
 TI    Anti-neutrophil cytoplasm antibodies in HIV infection.
 DT    9404
 AU    Savige JA; Chang L; Crowe SM; University Department of Medicine, Austin
       Hospital, Heidelberg,; Victoria, Australia.
 SO    Adv Exp Med Biol. 1993;336:349-52. Unique Identifier : AIDSLINE
       MED/94127278
 AB    Sera from 105 HIV-infected patients were tested for anti-neutrophil
       cytoplasm antibodies (ANCA) by indirect immunofluorescence (IIF), by
       specific ELISAs using target proteins of ANCA and by a neutrophil
       cytoplasm extract ELISA. Forty-four sera were positive. These included
       18 positive by IIF, 7 with anti-neutrophil proteinase 3 antibodies, 26
       with anti-myeloperoxidase antibodies and 2 with anti-elastase
       antibodies. Four sera were positive in the neutrophil cytoplasm extract
       ELISA but not in the specific ELISAs. None of these patients had
       clinical evidence of a cutaneous or systemic vasculitis. In addition
       there was no correlation between the presence of ANCA and the stage of
       disease, intercurrent bacterial or viral infection, anti-nuclear
       antibodies (ANA) and positive hepatitis B or syphilis serology.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Autoantibodies/*BLOOD
       AIDS-Related Complex/IMMUNOLOGY  Enzyme-Linked Immunosorbent Assay
       Fluorescent Antibody Technique  Human  HIV Infections/*IMMUNOLOGY
       IgG/*BLOOD  Pancreatopeptidase/IMMUNOLOGY  Peroxidase/IMMUNOLOGY  Serine
       Proteinases/IMMUNOLOGY  JOURNAL ARTICLE

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