Document 0852
 DOCN  M9440852
 TI    Population dynamics of CD4+ T cells lacking Thy-1 in murine
       retrovirus-induced immunodeficiency syndrome (MAIDS).
 DT    9404
 AU    Moutschen MP; Colombi S; Deprez M; Van Wijk F; Hotermans C; Martin MT;
       Greimers R; Boniver J; Department of Pathology, University of Liege,
       Belgium.
 SO    Scand J Immunol. 1994 Feb;39(2):216-24. Unique Identifier : AIDSLINE
       MED/94126672
 AB    Increased numbers of CD4+ Thy-1- cells have been described in the spleen
       (SP) of mice with retrovirus-induced immunodeficiency (MAIDS). Since
       this phenotypic abnormality might have considerable functional
       importance, the expansion of the CD4+ Thy-1- subset in MAIDS was
       characterized further. CD4+ Thy-1- and Thy-1+ T-cells from infected mice
       expressed similar densities of CD3 and TCR alpha/beta. In contrast, the
       Thy-1- subset was uniformly CD44hi, even early in the disease when part
       of Thy-1+ cells were still CD44lo. The emergence of CD4+ Thy-1- cells
       occurred first in SP and lymph nodes and was observed later in thymus.
       The important fraction of CD4+ cells lacking Thy-1 normally present in
       Peyer's patches was only weakly modified. Despite the major expansion of
       the CD4+ Thy-1- phenotype, the proliferating fraction was not higher in
       this subset than in CD4+ Thy-1+ cells from infected mice. Persistence
       after hydroxyurea administration was identical in both subsets,
       indicating similar mean cell lifespans. Taken together, these results
       show that the major expansion of CD4+ Thy-1- T-cells in MAIDS is not
       ascribable solely to increased proliferation within this subset.
       Phenotypic analysis suggests that CD4+ Thy-1- cells result from the
       differentiation of Thy-1+ cells induced by activation signals related to
       retroviral infection.
 DE    Animal  Antigens, CD3/ANALYSIS  Antigens, Surface/ANALYSIS  Carrier
       Proteins/ANALYSIS  Leukocyte Count  Lymph Nodes/IMMUNOLOGY  Male
       Membrane Glycoproteins/ANALYSIS  Mice  Mice, Inbred C57BL  Murine
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Phenotype  Receptors,
       Antigen, T-Cell, alpha-beta/ANALYSIS  Receptors, Cell Surface/ANALYSIS
       Receptors, Lymphocyte Homing/ANALYSIS  Spleen/IMMUNOLOGY  Support,
       Non-U.S. Gov't  T-Lymphocyte Subsets/*IMMUNOLOGY  T4
       Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).