Document 0867
 DOCN  M9440867
 TI    Current and future HIV/AIDS clinical research. HIV-related therapy
       improving--slowly.
 DT    9404
 AU    Henry K; Schwebke K; HIV Program, St. Paul-Ramsey Medical Center.
 SO    Minn Med. 1993 Nov;76(11):17-23. Unique Identifier : AIDSLINE
       MED/94126039
 AB    More than 300,000 cases of AIDS have been reported in the United States
       since 1981. Despite major scientific advances and much effort, the
       benefits of treatment have been modest. The variable nature of the human
       immunodeficiency virus (HIV) and the complexity of the immune system are
       the major obstacles to advances in treatment. This article summarizes
       the current state of clinical research in pursuit of improved HIV
       therapy and takes a look into the future of anti-HIV therapeutics. It
       also provides an overview of HIV clinical research underway in
       Minnesota. Research efforts to improve therapy of HIV-induced immune
       deficiency will involve three strategies: better anti-HIV drugs and
       combinations of drugs aimed at slowing the replication of HIV,
       immune-based therapies intended to stimulate the immune system, and
       multiple opportunistic pathogen prophylaxis strategies to prevent
       HIV-related opportunistic infections. This approach will involve
       considerable cost and polypharmacy. Improvements in HIV/AIDS therapy are
       likely to occur incrementally, but the endeavor needs widespread support
       from patients, physicians, and the public. For now, the best strategy is
       prevention, which is where physicians can have the greatest impact on
       the epidemic.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*THERAPY  Antiviral
       Agents/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/IMMUNOLOGY/THERAPY  Human  HIV/DRUG EFFECTS/IMMUNOLOGY  HIV
       Infections/IMMUNOLOGY/*THERAPY  Immunotherapy/METHODS  Minnesota
       Research  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).